Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling

Protein:protein interactions are fundamental in living organism homeostasis. Here we introduce VHH6, a junctional epitope antibody capable of specifically recognizing a neo-epitope when two proteins interact, albeit transiently, to form a complex. Orthogonal biophysical techniques have been used to...

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Detalles Bibliográficos
Autores principales: Adams, Ralph, Burnley, Rebecca J., Valenzano, Chiara R., Qureshi, Omar, Doyle, Carl, Lumb, Simon, del Carmen Lopez, Maria, Griffin, Robert, McMillan, David, Taylor, Richard D., Meier, Chris, Mori, Prashant, Griffin, Laura M., Wernery, Ulrich, Kinne, Jörg, Rapecki, Stephen, Baker, Terry S., Lawson, Alastair D. G., Wright, Michael, Ettorre, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278397/
https://www.ncbi.nlm.nih.gov/pubmed/28134246
http://dx.doi.org/10.1038/srep37716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278397/
https://www.ncbi.nlm.nih.gov/pubmed/28134246
http://dx.doi.org/10.1038/srep37716

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