Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver

Dysfunction of cell-cell tight junction (TJ) adhesions is a major feature in the pathogenesis of various diseases. Liver TJs preserve cellular polarity by delimiting functional bile-canalicular structures, forming the blood-biliary barrier. In acetaminophen-hepatotoxicity, the mechanism by which tis...

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Detalles Bibliográficos
Autores principales: Gamal, Wesam, Treskes, Philipp, Samuel, Kay, Sullivan, Gareth J., Siller, Richard, Srsen, Vlastimil, Morgan, Katie, Bryans, Anna, Kozlowska, Ada, Koulovasilopoulos, Andreas, Underwood, Ian, Smith, Stewart, del-Pozo, Jorge, Moss, Sharon, Thompson, Alexandra Inés, Henderson, Neil C., Hayes, Peter C., Plevris, John N., Bagnaninchi, Pierre-Olivier, Nelson, Leonard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278402/
https://www.ncbi.nlm.nih.gov/pubmed/28134251
http://dx.doi.org/10.1038/srep37541

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