REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6

The circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in modulation of fertility. Here we show that lack of the clock component REV-ERBα elevates FGF21...

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Autores principales: Chavan, Rohit, Preitner, Nadia, Okabe, Takashi, Strittmatter, Laureen Mansencal, Xu, Cheng, Ripperger, Jürgen A., Pitteloud, Nelly, Albrecht, Urs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278426/
https://www.ncbi.nlm.nih.gov/pubmed/27875243
http://dx.doi.org/10.1242/bio.021519
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author Chavan, Rohit
Preitner, Nadia
Okabe, Takashi
Strittmatter, Laureen Mansencal
Xu, Cheng
Ripperger, Jürgen A.
Pitteloud, Nelly
Albrecht, Urs
author_facet Chavan, Rohit
Preitner, Nadia
Okabe, Takashi
Strittmatter, Laureen Mansencal
Xu, Cheng
Ripperger, Jürgen A.
Pitteloud, Nelly
Albrecht, Urs
author_sort Chavan, Rohit
collection PubMed
description The circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in modulation of fertility. Here we show that lack of the clock component REV-ERBα elevates FGF21 levels in liver and plasma. At the molecular level, REV-ERBα modulates the expression of FGF21 via the liver-specific hepatic nuclear factor 6 (HNF6). We conclude that REV-ERBα regulates metabolism and reproduction, at least in part, via regulation of Fgf21.
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spelling pubmed-52784262017-02-13 REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6 Chavan, Rohit Preitner, Nadia Okabe, Takashi Strittmatter, Laureen Mansencal Xu, Cheng Ripperger, Jürgen A. Pitteloud, Nelly Albrecht, Urs Biol Open Research Article The circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in modulation of fertility. Here we show that lack of the clock component REV-ERBα elevates FGF21 levels in liver and plasma. At the molecular level, REV-ERBα modulates the expression of FGF21 via the liver-specific hepatic nuclear factor 6 (HNF6). We conclude that REV-ERBα regulates metabolism and reproduction, at least in part, via regulation of Fgf21. The Company of Biologists Ltd 2016-11-14 /pmc/articles/PMC5278426/ /pubmed/27875243 http://dx.doi.org/10.1242/bio.021519 Text en © 2017. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article
Chavan, Rohit
Preitner, Nadia
Okabe, Takashi
Strittmatter, Laureen Mansencal
Xu, Cheng
Ripperger, Jürgen A.
Pitteloud, Nelly
Albrecht, Urs
REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6
title REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6
title_full REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6
title_fullStr REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6
title_full_unstemmed REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6
title_short REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6
title_sort rev-erbα regulates fgf21 expression in the liver via hepatic nuclear factor 6
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278426/
https://www.ncbi.nlm.nih.gov/pubmed/27875243
http://dx.doi.org/10.1242/bio.021519
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