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Lung ultrasound for the diagnosis of pneumonia in adults: A meta-analysis
BACKGROUND: Pneumonia is a common and serious infectious disease that can cause high mortality. The role of lung ultrasound (LUS) in the diagnosis of pneumonia is becoming more and more important. METHODS: In the present study, we collected existing evidence regarding the use of LUS to diagnose pneu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279077/ https://www.ncbi.nlm.nih.gov/pubmed/28099332 http://dx.doi.org/10.1097/MD.0000000000005713 |
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author | Long, Ling Zhao, Hao-Tian Zhang, Zhi-Yang Wang, Guang-Ying Zhao, He-Ling |
author_facet | Long, Ling Zhao, Hao-Tian Zhang, Zhi-Yang Wang, Guang-Ying Zhao, He-Ling |
author_sort | Long, Ling |
collection | PubMed |
description | BACKGROUND: Pneumonia is a common and serious infectious disease that can cause high mortality. The role of lung ultrasound (LUS) in the diagnosis of pneumonia is becoming more and more important. METHODS: In the present study, we collected existing evidence regarding the use of LUS to diagnose pneumonia in adults and conducted a systematic review to summarize the technique's diagnostic accuracy. We specifically searched the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, and Embase databases and retrieved outcome data to evaluate the efficacy of LUS for the diagnosis of pneumonia compared with chest radiography or chest computed tomography. The pooled sensitivity (SEN) and specificity (SPE) were determined using the Mantel–Haenszel method, and the pooled diagnostic odds ratio (DOR) was determined using the DerSimonian–Laird method. We also assessed heterogeneity of sensitivity, specificity, and diagnostic odds ratio using the Q and I(2) statistics. RESULTS: Twelve studies containing 1515 subjects were included in our meta-analysis. The SEN and SPE were 0.88 (95% CI: 0.86–0.90) and 0.86 (95% CI: 0.83–0.88), respectively. The pooled negative likelihood ratio (LR) was 0.13 (95% CI: 0.08–0.23), the positive LR was 5.37 (95% CI: 2.76–10.43), and the DOR was 65.46 (95% CI: 29.24–146.56). The summary receiver operating characteristic curve indicated a relationship between sensitivity and specificity. The area under the curve for LUS was 0.95. CONCLUSION: LUS can help to diagnose adult pneumonia with high accuracy. |
format | Online Article Text |
id | pubmed-5279077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-52790772017-02-08 Lung ultrasound for the diagnosis of pneumonia in adults: A meta-analysis Long, Ling Zhao, Hao-Tian Zhang, Zhi-Yang Wang, Guang-Ying Zhao, He-Ling Medicine (Baltimore) 4100 BACKGROUND: Pneumonia is a common and serious infectious disease that can cause high mortality. The role of lung ultrasound (LUS) in the diagnosis of pneumonia is becoming more and more important. METHODS: In the present study, we collected existing evidence regarding the use of LUS to diagnose pneumonia in adults and conducted a systematic review to summarize the technique's diagnostic accuracy. We specifically searched the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, and Embase databases and retrieved outcome data to evaluate the efficacy of LUS for the diagnosis of pneumonia compared with chest radiography or chest computed tomography. The pooled sensitivity (SEN) and specificity (SPE) were determined using the Mantel–Haenszel method, and the pooled diagnostic odds ratio (DOR) was determined using the DerSimonian–Laird method. We also assessed heterogeneity of sensitivity, specificity, and diagnostic odds ratio using the Q and I(2) statistics. RESULTS: Twelve studies containing 1515 subjects were included in our meta-analysis. The SEN and SPE were 0.88 (95% CI: 0.86–0.90) and 0.86 (95% CI: 0.83–0.88), respectively. The pooled negative likelihood ratio (LR) was 0.13 (95% CI: 0.08–0.23), the positive LR was 5.37 (95% CI: 2.76–10.43), and the DOR was 65.46 (95% CI: 29.24–146.56). The summary receiver operating characteristic curve indicated a relationship between sensitivity and specificity. The area under the curve for LUS was 0.95. CONCLUSION: LUS can help to diagnose adult pneumonia with high accuracy. Wolters Kluwer Health 2017-01-20 /pmc/articles/PMC5279077/ /pubmed/28099332 http://dx.doi.org/10.1097/MD.0000000000005713 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 4100 Long, Ling Zhao, Hao-Tian Zhang, Zhi-Yang Wang, Guang-Ying Zhao, He-Ling Lung ultrasound for the diagnosis of pneumonia in adults: A meta-analysis |
title | Lung ultrasound for the diagnosis of pneumonia in adults: A meta-analysis |
title_full | Lung ultrasound for the diagnosis of pneumonia in adults: A meta-analysis |
title_fullStr | Lung ultrasound for the diagnosis of pneumonia in adults: A meta-analysis |
title_full_unstemmed | Lung ultrasound for the diagnosis of pneumonia in adults: A meta-analysis |
title_short | Lung ultrasound for the diagnosis of pneumonia in adults: A meta-analysis |
title_sort | lung ultrasound for the diagnosis of pneumonia in adults: a meta-analysis |
topic | 4100 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279077/ https://www.ncbi.nlm.nih.gov/pubmed/28099332 http://dx.doi.org/10.1097/MD.0000000000005713 |
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