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Macrophage TGF-β1 and the Proapoptotic Extracellular Matrix Protein BIGH3 Induce Renal Cell Apoptosis in Prediabetic and Diabetic Conditions

Metabolically stressed kidney is in part characterized by infiltrating macrophages and macrophage-derived TGF-β1 that promote the synthesis of various ECM molecules. TGF-β1 strongly enhances the expression of the gene TGFBI that encodes a cell-adhesion class, proapoptotic ECM protein called BIGH3. W...

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Detalles Bibliográficos
Autores principales:	Moritz, Robert J., LeBaron, Richard G., Phelix, Clyde F., Rupaimoole, Rajesha, Kim, Hong Seok, Tsin, Andrew, Asmis, Reto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279341/ https://www.ncbi.nlm.nih.gov/pubmed/28149671 http://dx.doi.org/10.4236/ijcm.2016.77055

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