More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?

It is widely accepted that the glucocorticoid receptor (GR), a ligand-regulated transcription factor that triggers anti-inflammatory responses, binds specific response elements as a homodimer. Here, we will discuss the original primary data that established this model and contrast it with a recent r...

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Detalles Bibliográficos
Autores principales: Presman, Diego M., Hager, Gordon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Point-of-View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279712/
https://www.ncbi.nlm.nih.gov/pubmed/27764575
http://dx.doi.org/10.1080/21541264.2016.1249045
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author Presman, Diego M.
Hager, Gordon L.
author_facet Presman, Diego M.
Hager, Gordon L.
author_sort Presman, Diego M.
collection PubMed
description It is widely accepted that the glucocorticoid receptor (GR), a ligand-regulated transcription factor that triggers anti-inflammatory responses, binds specific response elements as a homodimer. Here, we will discuss the original primary data that established this model and contrast it with a recent report characterizing the GR–DNA complex as a tetramer.
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spelling pubmed-52797122017-02-22 More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor? Presman, Diego M. Hager, Gordon L. Transcription Point-of-View It is widely accepted that the glucocorticoid receptor (GR), a ligand-regulated transcription factor that triggers anti-inflammatory responses, binds specific response elements as a homodimer. Here, we will discuss the original primary data that established this model and contrast it with a recent report characterizing the GR–DNA complex as a tetramer. Taylor & Francis 2016-10-20 /pmc/articles/PMC5279712/ /pubmed/27764575 http://dx.doi.org/10.1080/21541264.2016.1249045 Text en © 2017 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Point-of-View
Presman, Diego M.
Hager, Gordon L.
More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?
title More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?
title_full More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?
title_fullStr More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?
title_full_unstemmed More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?
title_short More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?
title_sort more than meets the dimer: what is the quaternary structure of the glucocorticoid receptor?
topic Point-of-View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279712/
https://www.ncbi.nlm.nih.gov/pubmed/27764575
http://dx.doi.org/10.1080/21541264.2016.1249045
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