Dynamic chromatin regulation at Notch target genes

RBPJ is the central transcription factor that controls the Notch-dependent transcriptional response by coordinating repressing histone H3K27 deacetylation and activating histone H3K4 methylation. Here, we discuss the molecular mechanisms how RBPJ interacts with opposing NCoR/HDAC-corepressing or KMT...

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Detalles Bibliográficos
Autores principales: Giaimo, Benedetto Daniele, Oswald, Franz, Borggrefe, Tilman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Point-of-View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279717/
https://www.ncbi.nlm.nih.gov/pubmed/28027012
http://dx.doi.org/10.1080/21541264.2016.1265702
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author Giaimo, Benedetto Daniele
Oswald, Franz
Borggrefe, Tilman
author_facet Giaimo, Benedetto Daniele
Oswald, Franz
Borggrefe, Tilman
author_sort Giaimo, Benedetto Daniele
collection PubMed
description RBPJ is the central transcription factor that controls the Notch-dependent transcriptional response by coordinating repressing histone H3K27 deacetylation and activating histone H3K4 methylation. Here, we discuss the molecular mechanisms how RBPJ interacts with opposing NCoR/HDAC-corepressing or KMT2D/UTX-coactivating complexes and how this is controlled by phosphorylation of chromatin modifiers.
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spelling pubmed-52797172017-02-22 Dynamic chromatin regulation at Notch target genes Giaimo, Benedetto Daniele Oswald, Franz Borggrefe, Tilman Transcription Point-of-View RBPJ is the central transcription factor that controls the Notch-dependent transcriptional response by coordinating repressing histone H3K27 deacetylation and activating histone H3K4 methylation. Here, we discuss the molecular mechanisms how RBPJ interacts with opposing NCoR/HDAC-corepressing or KMT2D/UTX-coactivating complexes and how this is controlled by phosphorylation of chromatin modifiers. Taylor & Francis 2016-12-27 /pmc/articles/PMC5279717/ /pubmed/28027012 http://dx.doi.org/10.1080/21541264.2016.1265702 Text en © 2017 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Point-of-View
Giaimo, Benedetto Daniele
Oswald, Franz
Borggrefe, Tilman
Dynamic chromatin regulation at Notch target genes
title Dynamic chromatin regulation at Notch target genes
title_full Dynamic chromatin regulation at Notch target genes
title_fullStr Dynamic chromatin regulation at Notch target genes
title_full_unstemmed Dynamic chromatin regulation at Notch target genes
title_short Dynamic chromatin regulation at Notch target genes
title_sort dynamic chromatin regulation at notch target genes
topic Point-of-View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279717/
https://www.ncbi.nlm.nih.gov/pubmed/28027012
http://dx.doi.org/10.1080/21541264.2016.1265702
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