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Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells
A large number of drugs can induce prolongation of cardiac repolarization and life-threatening cardiac arrhythmias. The prediction of this side effect is however challenging as it usually develops in some genetically predisposed individuals with normal cardiac repolarization at baseline. Here, we de...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279943/ https://www.ncbi.nlm.nih.gov/pubmed/28134617 http://dx.doi.org/10.7554/eLife.19406 |