Cooperative and acute inhibition by multiple C-terminal motifs of L-type Ca(2+) channels

Inhibitions and antagonists of L-type Ca(2+) channels are important to both research and therapeutics. Here, we report C-terminus mediated inhibition (CMI) for Ca(V)1.3 that multiple motifs coordinate to tune down Ca(2+) current and Ca(2+) influx toward the lower limits determined by end-stage CDI (...

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Detalles Bibliográficos
Autores principales: Liu, Nan, Yang, Yaxiong, Ge, Lin, Liu, Min, Colecraft, Henry M, Liu, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279948/
https://www.ncbi.nlm.nih.gov/pubmed/28059704
http://dx.doi.org/10.7554/eLife.21989

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