Cargando…

RNA Interference of Human α-Synuclein in Mouse

α-Synuclein is postulated to play a key role in the pathogenesis of Parkinson’s disease (PD). Aggregates of α-synuclein contribute to neurodegeneration and cell death in humans and in mouse models of PD. Here, we use virally mediated RNA interference to knockdown human α-synuclein in mice. We used a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Young-Cho, Miller, Adam, Lins, Livia C. R. F., Han, Sang-Woo, Keiser, Megan S., Boudreau, Ryan L., Davidson, Beverly L., Narayanan, Nandakumar S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5281542/ https://www.ncbi.nlm.nih.gov/pubmed/28197125 http://dx.doi.org/10.3389/fneur.2017.00013

Ejemplares similares

Altered Gut Microbiome in Parkinson’s Disease and the Influence of Lipopolysaccharide in a Human α-Synuclein Over-Expressing Mouse Model
por: Gorecki, Anastazja M., et al.
Publicado: (2019)

Untangling the Manganese-α-Synuclein Web
por: Peres, Tanara Vieira, et al.
Publicado: (2016)

Versatile Structures of α-Synuclein
por: Wang, Chuchu, et al.
Publicado: (2016)

The Non-amyloidal Component Region of α-Synuclein Is Important for α-Synuclein Transport Within Axons
por: Anderson, Eric N., et al.
Publicado: (2020)

Nanoparticles With Affinity for α-Synuclein Sequester α-Synuclein to Form Toxic Aggregates in Neurons With Endolysosomal Impairment
por: Jiang, Peizhou, et al.
Publicado: (2021)

Import and Export of Misfolded α-Synuclein
por: Rodriguez, Lilia, et al.
Publicado: (2018)

SUMOylation in α-Synuclein Homeostasis and Pathology
por: Savyon, Mor, et al.
Publicado: (2020)

Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia
por: Sackmann, Valerie, et al.
Publicado: (2019)

Commentary: α-Synuclein Interacts with Lipoproteins in Plasma
por: Surguchov, Andrei
Publicado: (2017)

Biomarkers and the Role of α-Synuclein in Parkinson’s Disease
por: Du, Tingting, et al.
Publicado: (2021)

Palmitic Acid-Enriched Diet Increases α-Synuclein and Tyrosine Hydroxylase Expression Levels in the Mouse Brain
por: Schommer, Jared, et al.
Publicado: (2018)

The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson’s disease
por: Meng, Lanxia, et al.
Publicado: (2023)

Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein
por: Martinez Hernandez, Ana, et al.
Publicado: (2021)

α-Synuclein Alters Toll-Like Receptor Expression
por: Béraud, Dawn, et al.
Publicado: (2011)

Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease
por: Bridi, Jessika C., et al.
Publicado: (2018)

Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation
por: Vieira, Bruno Di Marco, et al.
Publicado: (2015)

Saturation mutagenesis of α-synuclein reveals monomer fold that modulates aggregation
por: Chlebowicz, Julita, et al.
Publicado: (2023)

Anionic nanoplastic contaminants promote Parkinson’s disease–associated α-synuclein aggregation
por: Liu, Zhiyong, et al.
Publicado: (2023)

Novel subcellular localization for α-synuclein: possible functional consequences
por: Guardia-Laguarta, Cristina, et al.
Publicado: (2015)

Effect of L-DOPA/Benserazide on Propagation of Pathological α-Synuclein
por: Shimozawa, Aki, et al.
Publicado: (2019)

α-Synuclein Regulates Peripheral Insulin Secretion and Glucose Transport
por: Wijesekara, Nadeeja, et al.
Publicado: (2021)

α-synuclein pathogenesis in hiPSC models of Parkinson’s disease
por: Baena-Montes, Jara M., et al.
Publicado: (2021)

The role of the endolysosomal pathway in α-synuclein pathogenesis in Parkinson’s disease
por: Smith, Jessica K., et al.
Publicado: (2023)

Uric acid regulates α-synuclein transmission in Parkinsonian models
por: Shin, Yu Jin, et al.
Publicado: (2023)

Lymphocyte Activation Gene 3 (Lag3) Contributes to α-Synucleinopathy in α-Synuclein Transgenic Mice
por: Gu, Hao, et al.
Publicado: (2021)

Injection of α-syn-98 Aggregates Into the Brain Triggers α-Synuclein Pathology and an Inflammatory Response
por: Du, Tingfu, et al.
Publicado: (2019)

Gut Microbiome-Modified Polyphenolic Compounds Inhibit α-Synuclein Seeding and Spreading in α-Synucleinopathies
por: Yamasaki, Tritia R., et al.
Publicado: (2020)

Analysis of α-Synuclein Pathology in PINK1 Knockout Rat Brains
por: Creed, Rose B., et al.
Publicado: (2019)

α-Synuclein: A Multifunctional Player in Exocytosis, Endocytosis, and Vesicle Recycling
por: Huang, Mingzhu, et al.
Publicado: (2019)

Lipids as Trans-Acting Effectors for α-Synuclein in the Pathogenesis of Parkinson’s Disease
por: Ikenaka, Kensuke, et al.
Publicado: (2019)

Lipids at the Crossroad of α-Synuclein Function and Dysfunction: Biological and Pathological Implications
por: Alza, Natalia P., et al.
Publicado: (2019)

α-Synuclein and Noradrenergic Modulation of Immune Cells in Parkinson’s Disease Pathogenesis
por: Butkovich, Laura M., et al.
Publicado: (2018)

Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved
por: Vasili, Eftychia, et al.
Publicado: (2019)

The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson’s Diseases
por: Zhang, Jiaming, et al.
Publicado: (2019)

From Synaptic Protein to Prion: The Long and Controversial Journey of α-Synuclein
por: Heras-Garvin, Antonio, et al.
Publicado: (2020)

LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson’s Disease?
por: O’Hara, Darren M., et al.
Publicado: (2020)

α-synuclein strains that cause distinct pathologies differentially inhibit proteasome
por: Suzuki, Genjiro, et al.
Publicado: (2020)

Pathogenic Mutations Differentially Regulate Cell-to-Cell Transmission of α-Synuclein
por: Guan, Yuan, et al.
Publicado: (2020)

Voltage-Gated Calcium Channels and α-Synuclein: Implications in Parkinson’s Disease
por: Leandrou, Emmanouela, et al.
Publicado: (2019)

Silica Nanoparticles Promote α-Synuclein Aggregation and Parkinson’s Disease Pathology
por: Yuan, Xin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_25ajfsgchf951gg3qdh11fde8q