Cargando…

Inhibition of Intermediate-Conductance Calcium-Activated K Channel (KCa3.1) and Fibroblast Mitogenesis by α-Linolenic Acid and Alterations of Channel Expression in the Lysosomal Storage Disorders, Fabry Disease, and Niemann Pick C

The calcium/calmodulin-gated KCa3.1 channel regulates normal and abnormal mitogenesis by controlling K(+)-efflux, cell volume, and membrane hyperpolarization-driven calcium-entry. Recent studies suggest modulation of KCa3.1 by omega-3 fatty acids as negative modulators and impaired KCa3.1 functions...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oliván-Viguera, Aida, Lozano-Gerona, Javier, López de Frutos, Laura, Cebolla, Jorge J., Irún, Pilar, Abarca-Lachen, Edgar, García-Malinis, Ana J., García-Otín, Ángel Luis, Gilaberte, Yolanda, Giraldo, Pilar, Köhler, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5281581/ https://www.ncbi.nlm.nih.gov/pubmed/28197106 http://dx.doi.org/10.3389/fphys.2017.00039

Ejemplares similares

Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes
por: Olivan-Viguera, Aida, et al.
Publicado: (2018)

Novel Phenolic Inhibitors of Small/Intermediate-Conductance Ca(2+)-Activated K(+) Channels, KCa3.1 and KCa2.3
por: Oliván-Viguera, Aida, et al.
Publicado: (2013)

Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis
por: Lozano-Gerona, Javier, et al.
Publicado: (2020)

KCa3.1 Transgene Induction in Murine Intestinal Epithelium Causes Duodenal Chyme Accumulation and Impairs Duodenal Contractility
por: Valero, Marta Sofía, et al.
Publicado: (2019)

Effects of KCa channels on biological behavior of trophoblasts
por: Zhang, Xiaolei, et al.
Publicado: (2022)

Contribution of the KCa3.1 channel–calmodulin interactions to the regulation of the KCa3.1 gating process
por: Morales, Patricia, et al.
Publicado: (2013)

Modeling interactions between voltage-gated Ca(2+) channels and KCa1.1 channels
por: Engbers, Jordan DT, et al.
Publicado: (2013)

Assessment of plasma chitotriosidase activity, CCL18/PARC concentration and NP-C suspicion index in the diagnosis of Niemann-Pick disease type C: a prospective observational study
por: De Castro-Orós, Isabel, et al.
Publicado: (2017)

Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1
por: Ji, Tianyang, et al.
Publicado: (2018)

GTP-dependent regulation of myometrial KCa channels incorporated into lipid bilayers
Publicado: (1990)

Characterization of the PCMBS-dependent modification of KCa3.1 channel gating
por: Bailey, Mark A., et al.
Publicado: (2010)

KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo
por: D'Alessandro, G, et al.
Publicado: (2013)

KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma
por: Brown, Brandon M., et al.
Publicado: (2018)

Genetic KCa3.1-Deficiency Produces Locomotor Hyperactivity and Alterations in Cerebral Monoamine Levels
por: Lambertsen, Kate Lykke, et al.
Publicado: (2012)

Correction: Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1
por: Ji, Tianyang, et al.
Publicado: (2018)

Modulation of K(Ca)3.1 Channels by Eicosanoids, Omega-3 Fatty Acids, and Molecular Determinants
por: Kacik, Michael, et al.
Publicado: (2014)

KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment
por: D'Alessandro, Giuseppina, et al.
Publicado: (2016)

Pharmacological Targeting of KCa Channels to Improve Endothelial Function in the Spontaneously Hypertensive Rat
por: Khaddaj Mallat, Rayan, et al.
Publicado: (2019)

Endothelial KCa channels: Novel targets to reduce atherosclerosis-driven vascular dysfunction
por: Vera, O. Daniel, et al.
Publicado: (2023)

Ceramide: a signal for apoptosis or mitogenesis?
Publicado: (1995)

Ion channels and pain in Fabry disease
por: Weissmann, Carina, et al.
Publicado: (2021)

Microglial KCa3.1 Channels as a Potential Therapeutic Target for Alzheimer's Disease
por: Maezawa, Izumi, et al.
Publicado: (2012)

Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1
por: Srivastava, Shekhar, et al.
Publicado: (2016)

The calcium-activated potassium channel KCa3.1 is an important modulator of hepatic injury
por: Sevelsted Møller, Linda, et al.
Publicado: (2016)

KCa3.1 ion channel: A novel therapeutic target for corneal fibrosis
por: Anumanthan, Govindaraj, et al.
Publicado: (2018)

Involvement of KCa3.1 channel activity in immediate perioperative cognitive and neuroinflammatory outcomes
por: Saxena, Sarah, et al.
Publicado: (2023)

High Expression of KCa3.1 in Patients with Clear Cell Renal Carcinoma Predicts High Metastatic Risk and Poor Survival
por: Rabjerg, Maj, et al.
Publicado: (2015)

Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease
por: Marques, André R. A., et al.
Publicado: (2016)

Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma
por: Catacuzzeno, Luigi, et al.
Publicado: (2012)

KCa3.1 and TRPM7 Channels at the Uropod Regulate Migration of Activated Human T Cells
por: Kuras, Zerrin, et al.
Publicado: (2012)

Functional Roles of the Ca(2+)-activated K(+) Channel, KCa3.1, in Brain Tumors
por: D’Alessandro, Giuseppina, et al.
Publicado: (2018)

Inhibition of lymphocyte mitogenesis by immobilized antigen-antibody complexes
Publicado: (1975)

Structural Determinants of the Closed KCa3.1 Channel Pore in Relation to Channel Gating: Results from a Substituted Cysteine Accessibility Analysis
por: Klein, Hélène, et al.
Publicado: (2007)

Complementary roles of KCa3.1 channels and β1-integrin during alveolar epithelial repair
por: Girault, Alban, et al.
Publicado: (2015)

The potassium channel KCa3.1 constitutes a pharmacological target for astrogliosis associated with ischemia stroke
por: Yi, Mengni, et al.
Publicado: (2017)

Activation of PKG and Akt Is Required for Cardioprotection by Ramelteon-Induced Preconditioning and Is Located Upstream of mKCa-Channels
por: Torregroza, Carolin, et al.
Publicado: (2020)

Tungstate-Targeting of BKαβ(1) Channels Tunes ERK Phosphorylation and Cell Proliferation in Human Vascular Smooth Muscle
por: Fernández-Mariño, Ana Isabel, et al.
Publicado: (2015)

Dynamin- and Rab5-Dependent Endocytosis of a Ca(2+)-Activated K(+) Channel, KCa2.3
por: Gao, Yajuan, et al.
Publicado: (2012)

High Glucose Induces CCL20 in Proximal Tubular Cells via Activation of the KCa3.1 Channel
por: Huang, Chunling, et al.
Publicado: (2014)

The Inhibition of KCa3.1 Channels Activity Reduces Cell Motility in Glioblastoma Derived Cancer Stem Cells
por: Ruggieri, Paola, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_hmtuml6pf4causfj1rf38v56fj