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On the Helix Propensity in Generalized Born Solvent Descriptions of Modeling the Dark Proteome
Intrinsically disordered proteins that populate the so-called “Dark Proteome” offer challenging benchmarks of atomistic simulation methods to accurately model conformational transitions on a multidimensional energy landscape. This work explores the application of parallel tempering with implicit sol...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5281587/ https://www.ncbi.nlm.nih.gov/pubmed/28197405 http://dx.doi.org/10.3389/fmolb.2017.00003 |