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Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences
Following the discovery that the amyloid precursor protein (APP) is the source of β-amyloid peptides (Aβ) that accumulate in Alzheimer’s disease (AD), structural analyses suggested that the holoprotein resembles a transmembrane receptor. Initial studies using reconstituted membranes demonstrated tha...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5281615/ https://www.ncbi.nlm.nih.gov/pubmed/28197070 http://dx.doi.org/10.3389/fnmol.2017.00003 |