Positron emission tomography measurement of brain MAO-B inhibition in patients with Alzheimer’s disease and elderly controls after oral administration of sembragiline

PURPOSE: In Alzheimer’s disease (AD), increased metabolism of monoamines by monoamine oxidase type B (MAO-B) leads to the production of toxic reactive oxygen species (ROS), which are thought to contribute to disease pathogenesis. Inhibition of the MAO-B enzyme may restore brain levels of monoaminerg...

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Detalles Bibliográficos
Autores principales: Sturm, Stefan, Forsberg, Anton, Nave, Stephane, Stenkrona, Per, Seneca, Nicholas, Varrone, Andrea, Comley, Robert A., Fazio, Patrik, Jamois, Candice, Nakao, Ryuji, Ejduk, Zbigniew, Al-Tawil, Nabil, Akenine, Ulrika, Halldin, Christer, Andreasen, Niels, Ricci, Benedicte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5281649/
https://www.ncbi.nlm.nih.gov/pubmed/27633250
http://dx.doi.org/10.1007/s00259-016-3510-6

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