Cargando…
Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis
Polymyositis (PM) is a chronic disease characterized by muscle pain, weakness, and increase in muscle-related enzymes, accompanied with inflammations in lymphocytes. However, it is not well understood how the molecular alternations in lymphocytes contribute to the development of polymyositis. The me...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282408/ https://www.ncbi.nlm.nih.gov/pubmed/28194428 http://dx.doi.org/10.1155/2017/3262384 |
_version_ | 1782503314530762752 |
---|---|
author | Yin, Geng Wang, Ying Cen, Xiao-min Yang, Yuan Yang, Min Xie, Qi-bing |
author_facet | Yin, Geng Wang, Ying Cen, Xiao-min Yang, Yuan Yang, Min Xie, Qi-bing |
author_sort | Yin, Geng |
collection | PubMed |
description | Polymyositis (PM) is a chronic disease characterized by muscle pain, weakness, and increase in muscle-related enzymes, accompanied with inflammations in lymphocytes. However, it is not well understood how the molecular alternations in lymphocytes contribute to the development of polymyositis. The mechanistic target of rapamycin (mTOR) signaling is the central regulator of metabolism and inflammation in mammalian cells. Based on previous studies, we proposed that mTOR signaling may control inflammatory reactions via lipid metabolism. In this study, we aim to figure out the role of mTOR signaling in the development of polymyositis and identify novel biomarkers for the detection and therapy of polymyositis. After screening and validation, we found that palmitoleic acid, a monounsaturated fatty acid, is highly regulated by mTOR signaling. Inhibition of mTORC1 activity decreases palmitoleic acid level. Moreover, mTORC1 regulates the level of palmitoleic acid by controlling its de novo synthesis. Importantly, increased palmitoleic acid has been proven to be a marker of polymyositis. Our work identifies palmitoleic acid in peripheral blood mononuclear cells (PBMC) as a biomarker of polymyositis and offers new targets to the clinical therapy. |
format | Online Article Text |
id | pubmed-5282408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-52824082017-02-13 Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis Yin, Geng Wang, Ying Cen, Xiao-min Yang, Yuan Yang, Min Xie, Qi-bing J Immunol Res Research Article Polymyositis (PM) is a chronic disease characterized by muscle pain, weakness, and increase in muscle-related enzymes, accompanied with inflammations in lymphocytes. However, it is not well understood how the molecular alternations in lymphocytes contribute to the development of polymyositis. The mechanistic target of rapamycin (mTOR) signaling is the central regulator of metabolism and inflammation in mammalian cells. Based on previous studies, we proposed that mTOR signaling may control inflammatory reactions via lipid metabolism. In this study, we aim to figure out the role of mTOR signaling in the development of polymyositis and identify novel biomarkers for the detection and therapy of polymyositis. After screening and validation, we found that palmitoleic acid, a monounsaturated fatty acid, is highly regulated by mTOR signaling. Inhibition of mTORC1 activity decreases palmitoleic acid level. Moreover, mTORC1 regulates the level of palmitoleic acid by controlling its de novo synthesis. Importantly, increased palmitoleic acid has been proven to be a marker of polymyositis. Our work identifies palmitoleic acid in peripheral blood mononuclear cells (PBMC) as a biomarker of polymyositis and offers new targets to the clinical therapy. Hindawi Publishing Corporation 2017 2017-01-17 /pmc/articles/PMC5282408/ /pubmed/28194428 http://dx.doi.org/10.1155/2017/3262384 Text en Copyright © 2017 Geng Yin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yin, Geng Wang, Ying Cen, Xiao-min Yang, Yuan Yang, Min Xie, Qi-bing Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis |
title | Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis |
title_full | Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis |
title_fullStr | Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis |
title_full_unstemmed | Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis |
title_short | Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis |
title_sort | identification of palmitoleic acid controlled by mtor signaling as a biomarker of polymyositis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282408/ https://www.ncbi.nlm.nih.gov/pubmed/28194428 http://dx.doi.org/10.1155/2017/3262384 |
work_keys_str_mv | AT yingeng identificationofpalmitoleicacidcontrolledbymtorsignalingasabiomarkerofpolymyositis AT wangying identificationofpalmitoleicacidcontrolledbymtorsignalingasabiomarkerofpolymyositis AT cenxiaomin identificationofpalmitoleicacidcontrolledbymtorsignalingasabiomarkerofpolymyositis AT yangyuan identificationofpalmitoleicacidcontrolledbymtorsignalingasabiomarkerofpolymyositis AT yangmin identificationofpalmitoleicacidcontrolledbymtorsignalingasabiomarkerofpolymyositis AT xieqibing identificationofpalmitoleicacidcontrolledbymtorsignalingasabiomarkerofpolymyositis |