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Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis

Morinda citrifolia L. (noni) has been shown to treat different disorders. However, data concerning its role in the treatment of intestinal inflammation still require clarification. In the current study, we investigated the effects of noni fruit juice (NFJ) in the treatment of C57BL/6 mice, which wer...

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Autores principales: Coutinho de Sousa, Beatriz, Reis Machado, Juliana, da Silva, Marcos Vinicius, da Costa, Thiago Alvares, Lazo-Chica, Javier Emilio, Degasperi, Thatiane do Prado, Rodrigues Junior, Virmondes, Sales-Campos, Helioswilton, Uber Bucek, Elizabeth, Freire Oliveira, Carlo José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282445/
https://www.ncbi.nlm.nih.gov/pubmed/28194046
http://dx.doi.org/10.1155/2017/6567432
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author Coutinho de Sousa, Beatriz
Reis Machado, Juliana
da Silva, Marcos Vinicius
da Costa, Thiago Alvares
Lazo-Chica, Javier Emilio
Degasperi, Thatiane do Prado
Rodrigues Junior, Virmondes
Sales-Campos, Helioswilton
Uber Bucek, Elizabeth
Freire Oliveira, Carlo José
author_facet Coutinho de Sousa, Beatriz
Reis Machado, Juliana
da Silva, Marcos Vinicius
da Costa, Thiago Alvares
Lazo-Chica, Javier Emilio
Degasperi, Thatiane do Prado
Rodrigues Junior, Virmondes
Sales-Campos, Helioswilton
Uber Bucek, Elizabeth
Freire Oliveira, Carlo José
author_sort Coutinho de Sousa, Beatriz
collection PubMed
description Morinda citrifolia L. (noni) has been shown to treat different disorders. However, data concerning its role in the treatment of intestinal inflammation still require clarification. In the current study, we investigated the effects of noni fruit juice (NFJ) in the treatment of C57BL/6 mice, which were continuously exposed to dextran sulfate sodium (DSS) for 9 consecutive days. NFJ consumption had no impact on the reduction of the clinical signs of the disease or on weight loss. Nonetheless, when a dilution of 1 : 10 was used, the intestinal architecture of the mice was preserved, accompanied by a reduction in the inflammatory infiltrate. Regardless of the concentration of NFJ, a decrease in both the activity of myeloperoxidase and the key inflammatory cytokines, TNF-α and IFN-γ, was also observed in the intestine. Furthermore, when NFJ was diluted 1 : 10 and 1 : 100, a reduction in the production of nitric oxide and IL-17 was detected in gut homogenates. Overall, the treatment with NFJ was effective in different aspects associated with disease progression and worsening. These results may point to noni fruit as an important source of anti-inflammatory molecules with a great potential to inhibit the progression of inflammatory diseases, such as inflammatory bowel disease.
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spelling pubmed-52824452017-02-13 Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis Coutinho de Sousa, Beatriz Reis Machado, Juliana da Silva, Marcos Vinicius da Costa, Thiago Alvares Lazo-Chica, Javier Emilio Degasperi, Thatiane do Prado Rodrigues Junior, Virmondes Sales-Campos, Helioswilton Uber Bucek, Elizabeth Freire Oliveira, Carlo José Mediators Inflamm Research Article Morinda citrifolia L. (noni) has been shown to treat different disorders. However, data concerning its role in the treatment of intestinal inflammation still require clarification. In the current study, we investigated the effects of noni fruit juice (NFJ) in the treatment of C57BL/6 mice, which were continuously exposed to dextran sulfate sodium (DSS) for 9 consecutive days. NFJ consumption had no impact on the reduction of the clinical signs of the disease or on weight loss. Nonetheless, when a dilution of 1 : 10 was used, the intestinal architecture of the mice was preserved, accompanied by a reduction in the inflammatory infiltrate. Regardless of the concentration of NFJ, a decrease in both the activity of myeloperoxidase and the key inflammatory cytokines, TNF-α and IFN-γ, was also observed in the intestine. Furthermore, when NFJ was diluted 1 : 10 and 1 : 100, a reduction in the production of nitric oxide and IL-17 was detected in gut homogenates. Overall, the treatment with NFJ was effective in different aspects associated with disease progression and worsening. These results may point to noni fruit as an important source of anti-inflammatory molecules with a great potential to inhibit the progression of inflammatory diseases, such as inflammatory bowel disease. Hindawi Publishing Corporation 2017 2017-01-17 /pmc/articles/PMC5282445/ /pubmed/28194046 http://dx.doi.org/10.1155/2017/6567432 Text en Copyright © 2017 Beatriz Coutinho de Sousa et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Coutinho de Sousa, Beatriz
Reis Machado, Juliana
da Silva, Marcos Vinicius
da Costa, Thiago Alvares
Lazo-Chica, Javier Emilio
Degasperi, Thatiane do Prado
Rodrigues Junior, Virmondes
Sales-Campos, Helioswilton
Uber Bucek, Elizabeth
Freire Oliveira, Carlo José
Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis
title Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis
title_full Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis
title_fullStr Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis
title_full_unstemmed Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis
title_short Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis
title_sort morinda citrifolia (noni) fruit juice reduces inflammatory cytokines expression and contributes to the maintenance of intestinal mucosal integrity in dss experimental colitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282445/
https://www.ncbi.nlm.nih.gov/pubmed/28194046
http://dx.doi.org/10.1155/2017/6567432
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