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Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis
Morinda citrifolia L. (noni) has been shown to treat different disorders. However, data concerning its role in the treatment of intestinal inflammation still require clarification. In the current study, we investigated the effects of noni fruit juice (NFJ) in the treatment of C57BL/6 mice, which wer...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282445/ https://www.ncbi.nlm.nih.gov/pubmed/28194046 http://dx.doi.org/10.1155/2017/6567432 |
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author | Coutinho de Sousa, Beatriz Reis Machado, Juliana da Silva, Marcos Vinicius da Costa, Thiago Alvares Lazo-Chica, Javier Emilio Degasperi, Thatiane do Prado Rodrigues Junior, Virmondes Sales-Campos, Helioswilton Uber Bucek, Elizabeth Freire Oliveira, Carlo José |
author_facet | Coutinho de Sousa, Beatriz Reis Machado, Juliana da Silva, Marcos Vinicius da Costa, Thiago Alvares Lazo-Chica, Javier Emilio Degasperi, Thatiane do Prado Rodrigues Junior, Virmondes Sales-Campos, Helioswilton Uber Bucek, Elizabeth Freire Oliveira, Carlo José |
author_sort | Coutinho de Sousa, Beatriz |
collection | PubMed |
description | Morinda citrifolia L. (noni) has been shown to treat different disorders. However, data concerning its role in the treatment of intestinal inflammation still require clarification. In the current study, we investigated the effects of noni fruit juice (NFJ) in the treatment of C57BL/6 mice, which were continuously exposed to dextran sulfate sodium (DSS) for 9 consecutive days. NFJ consumption had no impact on the reduction of the clinical signs of the disease or on weight loss. Nonetheless, when a dilution of 1 : 10 was used, the intestinal architecture of the mice was preserved, accompanied by a reduction in the inflammatory infiltrate. Regardless of the concentration of NFJ, a decrease in both the activity of myeloperoxidase and the key inflammatory cytokines, TNF-α and IFN-γ, was also observed in the intestine. Furthermore, when NFJ was diluted 1 : 10 and 1 : 100, a reduction in the production of nitric oxide and IL-17 was detected in gut homogenates. Overall, the treatment with NFJ was effective in different aspects associated with disease progression and worsening. These results may point to noni fruit as an important source of anti-inflammatory molecules with a great potential to inhibit the progression of inflammatory diseases, such as inflammatory bowel disease. |
format | Online Article Text |
id | pubmed-5282445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-52824452017-02-13 Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis Coutinho de Sousa, Beatriz Reis Machado, Juliana da Silva, Marcos Vinicius da Costa, Thiago Alvares Lazo-Chica, Javier Emilio Degasperi, Thatiane do Prado Rodrigues Junior, Virmondes Sales-Campos, Helioswilton Uber Bucek, Elizabeth Freire Oliveira, Carlo José Mediators Inflamm Research Article Morinda citrifolia L. (noni) has been shown to treat different disorders. However, data concerning its role in the treatment of intestinal inflammation still require clarification. In the current study, we investigated the effects of noni fruit juice (NFJ) in the treatment of C57BL/6 mice, which were continuously exposed to dextran sulfate sodium (DSS) for 9 consecutive days. NFJ consumption had no impact on the reduction of the clinical signs of the disease or on weight loss. Nonetheless, when a dilution of 1 : 10 was used, the intestinal architecture of the mice was preserved, accompanied by a reduction in the inflammatory infiltrate. Regardless of the concentration of NFJ, a decrease in both the activity of myeloperoxidase and the key inflammatory cytokines, TNF-α and IFN-γ, was also observed in the intestine. Furthermore, when NFJ was diluted 1 : 10 and 1 : 100, a reduction in the production of nitric oxide and IL-17 was detected in gut homogenates. Overall, the treatment with NFJ was effective in different aspects associated with disease progression and worsening. These results may point to noni fruit as an important source of anti-inflammatory molecules with a great potential to inhibit the progression of inflammatory diseases, such as inflammatory bowel disease. Hindawi Publishing Corporation 2017 2017-01-17 /pmc/articles/PMC5282445/ /pubmed/28194046 http://dx.doi.org/10.1155/2017/6567432 Text en Copyright © 2017 Beatriz Coutinho de Sousa et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Coutinho de Sousa, Beatriz Reis Machado, Juliana da Silva, Marcos Vinicius da Costa, Thiago Alvares Lazo-Chica, Javier Emilio Degasperi, Thatiane do Prado Rodrigues Junior, Virmondes Sales-Campos, Helioswilton Uber Bucek, Elizabeth Freire Oliveira, Carlo José Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis |
title |
Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis |
title_full |
Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis |
title_fullStr |
Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis |
title_full_unstemmed |
Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis |
title_short |
Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis |
title_sort | morinda citrifolia (noni) fruit juice reduces inflammatory cytokines expression and contributes to the maintenance of intestinal mucosal integrity in dss experimental colitis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282445/ https://www.ncbi.nlm.nih.gov/pubmed/28194046 http://dx.doi.org/10.1155/2017/6567432 |
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