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Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, partly because of the lack of effective treatments for DN. Curcumin has been shown to exert strong antifibrotic effects in DN, but the underlying mechanisms are not well characterized. In this study, we sought to determine th...

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Autores principales: Lu, Miaomiao, Yin, Nanchang, Liu, Wei, Cui, Xiangfei, Chen, Shuo, Wang, Ermin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282455/
https://www.ncbi.nlm.nih.gov/pubmed/28194406
http://dx.doi.org/10.1155/2017/1516985
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author Lu, Miaomiao
Yin, Nanchang
Liu, Wei
Cui, Xiangfei
Chen, Shuo
Wang, Ermin
author_facet Lu, Miaomiao
Yin, Nanchang
Liu, Wei
Cui, Xiangfei
Chen, Shuo
Wang, Ermin
author_sort Lu, Miaomiao
collection PubMed
description Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, partly because of the lack of effective treatments for DN. Curcumin has been shown to exert strong antifibrotic effects in DN, but the underlying mechanisms are not well characterized. In this study, we sought to determine the effects of curcumin on diabetic renal disease in db/db mice and characterize the underlying mechanism of action. We administered curcumin to db/db mice for 16 weeks. In comparison to mock-treated db/db mice, curcumin-treated mice showed diminished renal hypertrophy, reduced mesangial matrix expansion, and a lower level of albuminuria. Furthermore, the upregulated protein and mRNA expressions of collagen IV and fibronectin in the renal cortices of the db/db mice were inhibited by curcumin treatment. Additionally, curcumin treatment was associated with significant reductions in mature interleukin-1β, cleaved caspase-1, and NLRP3 protein levels in the renal cortices of db/db mice as well as in HK-2 cells exposed to high glucose concentration. In summary, curcumin, a potent antifibrotic agent, is a promising treatment for DN, and its renoprotective effects appear to be mediated by the inhibition of NLRP3 inflammasome activity.
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spelling pubmed-52824552017-02-13 Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling Lu, Miaomiao Yin, Nanchang Liu, Wei Cui, Xiangfei Chen, Shuo Wang, Ermin Biomed Res Int Research Article Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, partly because of the lack of effective treatments for DN. Curcumin has been shown to exert strong antifibrotic effects in DN, but the underlying mechanisms are not well characterized. In this study, we sought to determine the effects of curcumin on diabetic renal disease in db/db mice and characterize the underlying mechanism of action. We administered curcumin to db/db mice for 16 weeks. In comparison to mock-treated db/db mice, curcumin-treated mice showed diminished renal hypertrophy, reduced mesangial matrix expansion, and a lower level of albuminuria. Furthermore, the upregulated protein and mRNA expressions of collagen IV and fibronectin in the renal cortices of the db/db mice were inhibited by curcumin treatment. Additionally, curcumin treatment was associated with significant reductions in mature interleukin-1β, cleaved caspase-1, and NLRP3 protein levels in the renal cortices of db/db mice as well as in HK-2 cells exposed to high glucose concentration. In summary, curcumin, a potent antifibrotic agent, is a promising treatment for DN, and its renoprotective effects appear to be mediated by the inhibition of NLRP3 inflammasome activity. Hindawi Publishing Corporation 2017 2017-01-17 /pmc/articles/PMC5282455/ /pubmed/28194406 http://dx.doi.org/10.1155/2017/1516985 Text en Copyright © 2017 Miaomiao Lu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lu, Miaomiao
Yin, Nanchang
Liu, Wei
Cui, Xiangfei
Chen, Shuo
Wang, Ermin
Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling
title Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling
title_full Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling
title_fullStr Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling
title_full_unstemmed Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling
title_short Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling
title_sort curcumin ameliorates diabetic nephropathy by suppressing nlrp3 inflammasome signaling
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282455/
https://www.ncbi.nlm.nih.gov/pubmed/28194406
http://dx.doi.org/10.1155/2017/1516985
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