Cargando…

Increase of TREM2 during Aging of an Alzheimer’s Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis

Heterozygous missense mutations in the triggering receptor expressed on myeloid cells 2 (TREM2) have been reported to significantly increase the risk of developing Alzheimer’s disease (AD). Since TREM2 is specifically expressed by microglia in the brain, we hypothesized that soluble TREM2 (sTREM2) l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brendel, Matthias, Kleinberger, Gernot, Probst, Federico, Jaworska, Anna, Overhoff, Felix, Blume, Tanja, Albert, Nathalie L., Carlsen, Janette, Lindner, Simon, Gildehaus, Franz Josef, Ozmen, Laurence, Suárez-Calvet, Marc, Bartenstein, Peter, Baumann, Karlheinz, Ewers, Michael, Herms, Jochen, Haass, Christian, Rominger, Axel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282474/ https://www.ncbi.nlm.nih.gov/pubmed/28197095 http://dx.doi.org/10.3389/fnagi.2017.00008

Ejemplares similares

Automated Spatial Brain Normalization and Hindbrain White Matter Reference Tissue Give Improved [(18)F]-Florbetaben PET Quantitation in Alzheimer's Model Mice
por: Overhoff, Felix, et al.
Publicado: (2016)

Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation
por: Brendel, Matthias, et al.
Publicado: (2018)

Cross-Sectional Comparison of Small Animal [(18)F]-Florbetaben Amyloid-PET between Transgenic AD Mouse Models
por: Brendel, Matthias, et al.
Publicado: (2015)

Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study
por: Blume, Tanja, et al.
Publicado: (2018)

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation
por: Ewers, Michael, et al.
Publicado: (2020)

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism
por: Götzl, Julia K, et al.
Publicado: (2019)

Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment
por: Brendel, M, et al.
Publicado: (2015)

Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases
por: Biechele, Gloria, et al.
Publicado: (2020)

Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition
por: Blume, Tanja, et al.
Publicado: (2022)

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans
por: Xiang, Xianyuan, et al.
Publicado: (2018)

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration
por: Franzmeier, Nicolai, et al.
Publicado: (2020)

Loss of TREM2 function increases amyloid seeding but reduces plaque associated ApoE
por: Parhizkar, Samira, et al.
Publicado: (2019)

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
por: Xiang, Xianyuan, et al.
Publicado: (2016)

An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function
por: Schlepckow, Kai, et al.
Publicado: (2017)

sTREM2 is associated with amyloid‐related p‐tau increases and glucose hypermetabolism in Alzheimer's disease
por: Biel, Davina, et al.
Publicado: (2023)

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region
por: Schlepckow, Kai, et al.
Publicado: (2020)

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers
por: Suárez‐Calvet, Marc, et al.
Publicado: (2016)

Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation
por: Biechele, Gloria, et al.
Publicado: (2021)

Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
por: Suárez-Calvet, Marc, et al.
Publicado: (2019)

Comparison of (18)F-T807 and (18)F-THK5117 PET in a Mouse Model of Tau Pathology
por: Brendel, Matthias, et al.
Publicado: (2018)

Monitoring of Tumor Growth with [(18)F]-FET PET in a Mouse Model of Glioblastoma: SUV Measurements and Volumetric Approaches
por: Holzgreve, Adrien, et al.
Publicado: (2016)

The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
por: Gispert, Juan Domingo, et al.
Publicado: (2016)

Glitter in the Darkness? Nonfibrillar β-Amyloid Plaque Components Significantly Impact the β-Amyloid PET Signal in Mouse Models of Alzheimer Disease
por: Biechele, Gloria, et al.
Publicado: (2022)

Data on specificity of [(18)F]GE180 uptake for TSPO expression in rodent brain and myocardium
por: Deussing, Maximilian, et al.
Publicado: (2018)

TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities
por: Liu, Zhaoji, et al.
Publicado: (2020)

Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau
por: Brendel, Matthias, et al.
Publicado: (2019)

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline
por: Suárez‐Calvet, Marc, et al.
Publicado: (2018)

Dual-Phase β-Amyloid PET Captures Neuronal Injury and Amyloidosis in Corticobasal Syndrome
por: Schmitt, Julia, et al.
Publicado: (2021)

Reduced FDG-PET brain metabolism and executive function predict clinical progression in elderly healthy subjects()()
por: Ewers, Michael, et al.
Publicado: (2013)

Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study
por: Morenas-Rodríguez, Estrella, et al.
Publicado: (2022)

TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism
por: Zheng, Honghua, et al.
Publicado: (2018)

Mechanisms of Granulin Deficiency: Lessons from Cellular and Animal Models
por: Kleinberger, Gernot, et al.
Publicado: (2012)

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency
por: Reifschneider, Anika, et al.
Publicado: (2022)

TREM2 triggers microglial density and age‐related neuronal loss
por: Linnartz‐Gerlach, Bettina, et al.
Publicado: (2018)

Soluble TREM2 induces inflammatory responses and enhances microglial survival
por: Zhong, Li, et al.
Publicado: (2017)

Long-Term Pioglitazone Treatment Has No Significant Impact on Microglial Activation and Tau Pathology in P301S Mice
por: Kunze, Lea Helena, et al.
Publicado: (2023)

Perfusion-Phase [(18)F]THK5351 Tau-PET Imaging as a Surrogate Marker for Neurodegeneration
por: Brendel, Matthias, et al.
Publicado: (2017)

Assessment of synaptic loss in mouse models of β-amyloid and tau pathology using [(18)F]UCB-H PET imaging
por: Vogler, Letizia, et al.
Publicado: (2023)

Divergent Neuroinflammatory Regulation of Microglial TREM Expression and Involvement of NF-κB
por: Owens, Rosie, et al.
Publicado: (2017)

Modulation of microglial phenotypes by dexmedetomidine through TREM2 reduces neuroinflammation in heatstroke
por: Li, Ping, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qrtushhphhrvre4c4g1pbsopcd