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Prognostic value of marital status on stage at diagnosis in hepatocellular carcinoma

Marital status have been found as an independent prognostic factor for survival and spousal support could provide a survival advantage in various cancer types. However, the specific effect of marital status on survival in hepatocellular carcinoma (HCC) has not been explored in detail. In this study,...

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Autores principales: Zhang, Wenjie, Wang, Xiaochen, Huang, Ruyi, Jin, Kangpeng, Zhangyuan, Guangyan, Yu, Weiwei, Yin, Yin, Wang, Hai, Xu, Zekuan, Sun, Beicheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282486/
https://www.ncbi.nlm.nih.gov/pubmed/28139708
http://dx.doi.org/10.1038/srep41695
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author Zhang, Wenjie
Wang, Xiaochen
Huang, Ruyi
Jin, Kangpeng
Zhangyuan, Guangyan
Yu, Weiwei
Yin, Yin
Wang, Hai
Xu, Zekuan
Sun, Beicheng
author_facet Zhang, Wenjie
Wang, Xiaochen
Huang, Ruyi
Jin, Kangpeng
Zhangyuan, Guangyan
Yu, Weiwei
Yin, Yin
Wang, Hai
Xu, Zekuan
Sun, Beicheng
author_sort Zhang, Wenjie
collection PubMed
description Marital status have been found as an independent prognostic factor for survival and spousal support could provide a survival advantage in various cancer types. However, the specific effect of marital status on survival in hepatocellular carcinoma (HCC) has not been explored in detail. In this study, we used the Surveillance, Epidemiology and End Results program to identify iagnosed with HCC between 1988 and 2007. Kaplan-Meier methods and multivariable Cox regression models were used to analyze long-term cancer-specific survival (CSS) outcomes and risk factors stratified by marital status. There were significant differences among these different marital status subgroups with regard to 5-year CSS rates (P < 0.001). Married HCC patients had a better 5 year CSS rate than those unmarried patients, and widowed patients were more likely to die of their cancer. A stratified analysis showed that widowed patients always had the lowest CSS rate across different cancer stage, age and gender subgroups. Even after adjusting for known confounders, unmarried patients were at greater risk of cancer-specific mortality. Social support aimed at this population could improve the likelihood of achieving cure.
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spelling pubmed-52824862017-02-03 Prognostic value of marital status on stage at diagnosis in hepatocellular carcinoma Zhang, Wenjie Wang, Xiaochen Huang, Ruyi Jin, Kangpeng Zhangyuan, Guangyan Yu, Weiwei Yin, Yin Wang, Hai Xu, Zekuan Sun, Beicheng Sci Rep Article Marital status have been found as an independent prognostic factor for survival and spousal support could provide a survival advantage in various cancer types. However, the specific effect of marital status on survival in hepatocellular carcinoma (HCC) has not been explored in detail. In this study, we used the Surveillance, Epidemiology and End Results program to identify iagnosed with HCC between 1988 and 2007. Kaplan-Meier methods and multivariable Cox regression models were used to analyze long-term cancer-specific survival (CSS) outcomes and risk factors stratified by marital status. There were significant differences among these different marital status subgroups with regard to 5-year CSS rates (P < 0.001). Married HCC patients had a better 5 year CSS rate than those unmarried patients, and widowed patients were more likely to die of their cancer. A stratified analysis showed that widowed patients always had the lowest CSS rate across different cancer stage, age and gender subgroups. Even after adjusting for known confounders, unmarried patients were at greater risk of cancer-specific mortality. Social support aimed at this population could improve the likelihood of achieving cure. Nature Publishing Group 2017-01-31 /pmc/articles/PMC5282486/ /pubmed/28139708 http://dx.doi.org/10.1038/srep41695 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Wenjie
Wang, Xiaochen
Huang, Ruyi
Jin, Kangpeng
Zhangyuan, Guangyan
Yu, Weiwei
Yin, Yin
Wang, Hai
Xu, Zekuan
Sun, Beicheng
Prognostic value of marital status on stage at diagnosis in hepatocellular carcinoma
title Prognostic value of marital status on stage at diagnosis in hepatocellular carcinoma
title_full Prognostic value of marital status on stage at diagnosis in hepatocellular carcinoma
title_fullStr Prognostic value of marital status on stage at diagnosis in hepatocellular carcinoma
title_full_unstemmed Prognostic value of marital status on stage at diagnosis in hepatocellular carcinoma
title_short Prognostic value of marital status on stage at diagnosis in hepatocellular carcinoma
title_sort prognostic value of marital status on stage at diagnosis in hepatocellular carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282486/
https://www.ncbi.nlm.nih.gov/pubmed/28139708
http://dx.doi.org/10.1038/srep41695
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