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Cortisol Awakening Response and Acute Stress Reactivity in First Nations People

First Nations people globally have a higher incidence of mental disorders and non-communicable diseases. These health inequalities are partially attributed to a complex network of social and environmental factors which likely converge on chronic psychosocial stress. We hypothesized that alterations...

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Autores principales: Berger, Maximus, Leicht, Anthony, Slatcher, Angela, Kraeuter, Ann Katrin, Ketheesan, Sarangan, Larkins, Sarah, Sarnyai, Zoltán
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282508/
https://www.ncbi.nlm.nih.gov/pubmed/28139727
http://dx.doi.org/10.1038/srep41760
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author Berger, Maximus
Leicht, Anthony
Slatcher, Angela
Kraeuter, Ann Katrin
Ketheesan, Sarangan
Larkins, Sarah
Sarnyai, Zoltán
author_facet Berger, Maximus
Leicht, Anthony
Slatcher, Angela
Kraeuter, Ann Katrin
Ketheesan, Sarangan
Larkins, Sarah
Sarnyai, Zoltán
author_sort Berger, Maximus
collection PubMed
description First Nations people globally have a higher incidence of mental disorders and non-communicable diseases. These health inequalities are partially attributed to a complex network of social and environmental factors which likely converge on chronic psychosocial stress. We hypothesized that alterations in stress processing and the regulation of the hypothalamic-pituitary-adrenal axis might underlie health disparities in First Nations people. We assessed the cortisol awakening response and the dynamic response to a laboratory induced psychosocial stress of young Indigenous tertiary students (n = 11, mean age 23.82 years) and non-Indigenous students (n = 11) matched for age and gender. Indigenous participants had a blunted cortisol awakening response (27.40 (SD 35.00) vs. 95.24 (SD 55.23), p = 0.002), which was differentially associated with chronic experience of stress in Indigenous (r = −0.641, p = 0.046) and non-Indigenous (r = 0.652, p = 0.03) participants. The cortisol response to the laboratory induced psychosocial stress did not differ between groups. Self-reported racial discrimination was strongly associated with flattened cortisol response to stress (r = −0676, p = 0.022) and with heart rate variability (r = 0.654, p = 0.040). Our findings provide insight into potential biological factors underlying health discrepancies in ethnic minority groups.
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spelling pubmed-52825082017-02-03 Cortisol Awakening Response and Acute Stress Reactivity in First Nations People Berger, Maximus Leicht, Anthony Slatcher, Angela Kraeuter, Ann Katrin Ketheesan, Sarangan Larkins, Sarah Sarnyai, Zoltán Sci Rep Article First Nations people globally have a higher incidence of mental disorders and non-communicable diseases. These health inequalities are partially attributed to a complex network of social and environmental factors which likely converge on chronic psychosocial stress. We hypothesized that alterations in stress processing and the regulation of the hypothalamic-pituitary-adrenal axis might underlie health disparities in First Nations people. We assessed the cortisol awakening response and the dynamic response to a laboratory induced psychosocial stress of young Indigenous tertiary students (n = 11, mean age 23.82 years) and non-Indigenous students (n = 11) matched for age and gender. Indigenous participants had a blunted cortisol awakening response (27.40 (SD 35.00) vs. 95.24 (SD 55.23), p = 0.002), which was differentially associated with chronic experience of stress in Indigenous (r = −0.641, p = 0.046) and non-Indigenous (r = 0.652, p = 0.03) participants. The cortisol response to the laboratory induced psychosocial stress did not differ between groups. Self-reported racial discrimination was strongly associated with flattened cortisol response to stress (r = −0676, p = 0.022) and with heart rate variability (r = 0.654, p = 0.040). Our findings provide insight into potential biological factors underlying health discrepancies in ethnic minority groups. Nature Publishing Group 2017-01-31 /pmc/articles/PMC5282508/ /pubmed/28139727 http://dx.doi.org/10.1038/srep41760 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Berger, Maximus
Leicht, Anthony
Slatcher, Angela
Kraeuter, Ann Katrin
Ketheesan, Sarangan
Larkins, Sarah
Sarnyai, Zoltán
Cortisol Awakening Response and Acute Stress Reactivity in First Nations People
title Cortisol Awakening Response and Acute Stress Reactivity in First Nations People
title_full Cortisol Awakening Response and Acute Stress Reactivity in First Nations People
title_fullStr Cortisol Awakening Response and Acute Stress Reactivity in First Nations People
title_full_unstemmed Cortisol Awakening Response and Acute Stress Reactivity in First Nations People
title_short Cortisol Awakening Response and Acute Stress Reactivity in First Nations People
title_sort cortisol awakening response and acute stress reactivity in first nations people
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282508/
https://www.ncbi.nlm.nih.gov/pubmed/28139727
http://dx.doi.org/10.1038/srep41760
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