The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded C9ORF72 Inhibits the Proteasome

An intronic hexanucleotide repeat expansion (HRE) mutation in the C9ORF72 gene is the most common cause of familial ALS and frontotemporal dementia (FTD) and is found in ∼7% of individuals with apparently sporadic disease. Several different diamino acid peptides can be generated from the HRE by nonc...

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Detalles Bibliográficos
Autores principales: Gupta, Rahul, Lan, Matthews, Mojsilovic-Petrovic, Jelena, Choi, Won Hoon, Safren, Nathaniel, Barmada, Sami, Lee, Min Jae, Kalb, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2017
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282547/
https://www.ncbi.nlm.nih.gov/pubmed/28197542
http://dx.doi.org/10.1523/ENEURO.0249-16.2017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282547/
https://www.ncbi.nlm.nih.gov/pubmed/28197542
http://dx.doi.org/10.1523/ENEURO.0249-16.2017

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