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Polymorphism of apyrimidinic DNA structures in the nucleosome

Huge amounts (>10,000/day) of apurinic/apyrimidinic (AP) sites are produced in genomes, but their structures in chromatin remain undetermined. We determined the crystal structure of the nucleosome containing AP-site analogs at two symmetric sites, which revealed structural polymorphism: one forms...

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Detalles Bibliográficos
Autores principales:	Osakabe, Akihisa, Arimura, Yasuhiro, Matsumoto, Syota, Horikoshi, Naoki, Sugasawa, Kaoru, Kurumizaka, Hitoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282573/ https://www.ncbi.nlm.nih.gov/pubmed/28139742 http://dx.doi.org/10.1038/srep41783

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