The fibrogenic actions of lung fibroblast-derived urokinase: a potential drug target in IPF

The role of urokinase plasminogen activator (uPA) in idiopathic pulmonary fibrosis (IPF) remains unclear. uPA-generated plasmin has potent fibrogenic actions involving protease activated receptor-1 (PAR-1) and interleukin-6 (IL-6). Here we characterize uPA distribution or levels in lung tissue and s...

Descripción completa

Detalles Bibliográficos
Autores principales: Schuliga, Michael, Jaffar, Jade, Harris, Trudi, Knight, Darryl A, Westall, Glen, Stewart, Alastair G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282574/
https://www.ncbi.nlm.nih.gov/pubmed/28139758
http://dx.doi.org/10.1038/srep41770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282574/
https://www.ncbi.nlm.nih.gov/pubmed/28139758
http://dx.doi.org/10.1038/srep41770

Ejemplares similares