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The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores

The essential cochaperone Sgt1 recruits Hsp90 chaperone activity to a range of cellular factors including SCF E3 ubiquitin ligases and the kinetochore in eukaryotes. In these pathways Sgt1 interacts with Skp1, a small protein that heterodimerizes with proteins containing the F-box motif. We have det...

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Detalles Bibliográficos
Autores principales:	Willhoft, Oliver, Kerr, Richard, Patel, Dipali, Zhang, Wenjuan, Al-Jassar, Caezar, Daviter, Tina, Millson, Stefan H., Thalassinos, Konstantinos, Vaughan, Cara K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282575/ https://www.ncbi.nlm.nih.gov/pubmed/28139700 http://dx.doi.org/10.1038/srep41626

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