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Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis
Bronchiolitis is a major cause of hospitalization among infants. Severe bronchiolitis is associated with later asthma, suggesting a common genetic predisposition. Genetic background of bronchiolitis is not well characterized. To identify polymorphisms associated with bronchiolitis, we conducted a ge...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282585/ https://www.ncbi.nlm.nih.gov/pubmed/28139761 http://dx.doi.org/10.1038/srep41653 |
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author | Pasanen, Anu Karjalainen, Minna K. Bont, Louis Piippo-Savolainen, Eija Ruotsalainen, Marja Goksör, Emma Kumawat, Kuldeep Hodemaekers, Hennie Nuolivirta, Kirsi Jartti, Tuomas Wennergren, Göran Hallman, Mikko Rämet, Mika Korppi, Matti |
author_facet | Pasanen, Anu Karjalainen, Minna K. Bont, Louis Piippo-Savolainen, Eija Ruotsalainen, Marja Goksör, Emma Kumawat, Kuldeep Hodemaekers, Hennie Nuolivirta, Kirsi Jartti, Tuomas Wennergren, Göran Hallman, Mikko Rämet, Mika Korppi, Matti |
author_sort | Pasanen, Anu |
collection | PubMed |
description | Bronchiolitis is a major cause of hospitalization among infants. Severe bronchiolitis is associated with later asthma, suggesting a common genetic predisposition. Genetic background of bronchiolitis is not well characterized. To identify polymorphisms associated with bronchiolitis, we conducted a genome-wide association study (GWAS) in which 5,300,000 single nucleotide polymorphisms (SNPs) were tested for association in a Finnish–Swedish population of 217 children hospitalized for bronchiolitis and 778 controls. The most promising SNPs (n = 77) were genotyped in a Dutch replication population of 416 cases and 432 controls. Finally, we used a set of 202 Finnish bronchiolitis cases to further investigate candidate SNPs. We did not detect genome-wide significant associations, but several suggestive association signals (p < 10(−5)) were observed in the GWAS. In the replication population, three SNPs were nominally associated (p < 0.05). Of them, rs269094 was an expression quantitative trait locus (eQTL) for KCND3, previously shown to be associated with occupational asthma. In the additional set of Finnish cases, the association for another SNP (rs9591920) within a noncoding RNA locus was further strengthened. Our results provide a first genome-wide examination of the genetics underlying bronchiolitis. These preliminary findings require further validation in a larger sample size. |
format | Online Article Text |
id | pubmed-5282585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52825852017-02-03 Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis Pasanen, Anu Karjalainen, Minna K. Bont, Louis Piippo-Savolainen, Eija Ruotsalainen, Marja Goksör, Emma Kumawat, Kuldeep Hodemaekers, Hennie Nuolivirta, Kirsi Jartti, Tuomas Wennergren, Göran Hallman, Mikko Rämet, Mika Korppi, Matti Sci Rep Article Bronchiolitis is a major cause of hospitalization among infants. Severe bronchiolitis is associated with later asthma, suggesting a common genetic predisposition. Genetic background of bronchiolitis is not well characterized. To identify polymorphisms associated with bronchiolitis, we conducted a genome-wide association study (GWAS) in which 5,300,000 single nucleotide polymorphisms (SNPs) were tested for association in a Finnish–Swedish population of 217 children hospitalized for bronchiolitis and 778 controls. The most promising SNPs (n = 77) were genotyped in a Dutch replication population of 416 cases and 432 controls. Finally, we used a set of 202 Finnish bronchiolitis cases to further investigate candidate SNPs. We did not detect genome-wide significant associations, but several suggestive association signals (p < 10(−5)) were observed in the GWAS. In the replication population, three SNPs were nominally associated (p < 0.05). Of them, rs269094 was an expression quantitative trait locus (eQTL) for KCND3, previously shown to be associated with occupational asthma. In the additional set of Finnish cases, the association for another SNP (rs9591920) within a noncoding RNA locus was further strengthened. Our results provide a first genome-wide examination of the genetics underlying bronchiolitis. These preliminary findings require further validation in a larger sample size. Nature Publishing Group 2017-01-31 /pmc/articles/PMC5282585/ /pubmed/28139761 http://dx.doi.org/10.1038/srep41653 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Pasanen, Anu Karjalainen, Minna K. Bont, Louis Piippo-Savolainen, Eija Ruotsalainen, Marja Goksör, Emma Kumawat, Kuldeep Hodemaekers, Hennie Nuolivirta, Kirsi Jartti, Tuomas Wennergren, Göran Hallman, Mikko Rämet, Mika Korppi, Matti Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis |
title | Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis |
title_full | Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis |
title_fullStr | Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis |
title_full_unstemmed | Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis |
title_short | Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis |
title_sort | genome-wide association study of polymorphisms predisposing to bronchiolitis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282585/ https://www.ncbi.nlm.nih.gov/pubmed/28139761 http://dx.doi.org/10.1038/srep41653 |
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