The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model

Alzheimer’s disease (AD) is characterized by the accumulation of extracellular amyloid β-protein (Aβ) and intracellular hyperphosphorylated tau proteins. Recent evidence suggests that soluble Aβ oligomers elicit neurotoxicity and synaptotoxicity, including tau abnormalities, and play an initiating r...

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Detalles Bibliográficos
Autores principales: Tanokashira, Daisuke, Mamada, Naomi, Yamamoto, Fumiko, Taniguchi, Kaori, Tamaoka, Akira, Lakshmana, Madepalli K., Araki, Wataru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282621/
https://www.ncbi.nlm.nih.gov/pubmed/28137266
http://dx.doi.org/10.1186/s13041-016-0284-5

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