New isolations of the rabies-related Mokola virus from South Africa

BACKGROUND: Mokola virus (MOKV) is a rabies-related lyssavirus and appears to be exclusive to the African continent. Only 24 cases of MOKV, which includes two human cases, have been reported since its identification in 1968. MOKV has an unknown reservoir host and current commercial vaccines do not c...

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Autores principales: Coertse, Jessica, Markotter, Wanda, le Roux, Kevin, Stewart, Daniel, Sabeta, Claude T., Nel, Louis H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282659/
https://www.ncbi.nlm.nih.gov/pubmed/28143485
http://dx.doi.org/10.1186/s12917-017-0948-0
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author Coertse, Jessica
Markotter, Wanda
le Roux, Kevin
Stewart, Daniel
Sabeta, Claude T.
Nel, Louis H.
author_facet Coertse, Jessica
Markotter, Wanda
le Roux, Kevin
Stewart, Daniel
Sabeta, Claude T.
Nel, Louis H.
author_sort Coertse, Jessica
collection PubMed
description BACKGROUND: Mokola virus (MOKV) is a rabies-related lyssavirus and appears to be exclusive to the African continent. Only 24 cases of MOKV, which includes two human cases, have been reported since its identification in 1968. MOKV has an unknown reservoir host and current commercial vaccines do not confer protection against MOKV. RESULTS: We describe three new isolations of MOKV from domestic cats in South Africa. Two cases were retrospectively identified from 2012 and an additional one in 2014. CONCLUSIONS: These cases emphasize the generally poor surveillance for rabies-related lyssaviruses and our inadequate comprehension of the epidemiology and ecology of Mokola lyssavirus per se. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12917-017-0948-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-52826592017-02-03 New isolations of the rabies-related Mokola virus from South Africa Coertse, Jessica Markotter, Wanda le Roux, Kevin Stewart, Daniel Sabeta, Claude T. Nel, Louis H. BMC Vet Res Research Article BACKGROUND: Mokola virus (MOKV) is a rabies-related lyssavirus and appears to be exclusive to the African continent. Only 24 cases of MOKV, which includes two human cases, have been reported since its identification in 1968. MOKV has an unknown reservoir host and current commercial vaccines do not confer protection against MOKV. RESULTS: We describe three new isolations of MOKV from domestic cats in South Africa. Two cases were retrospectively identified from 2012 and an additional one in 2014. CONCLUSIONS: These cases emphasize the generally poor surveillance for rabies-related lyssaviruses and our inadequate comprehension of the epidemiology and ecology of Mokola lyssavirus per se. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12917-017-0948-0) contains supplementary material, which is available to authorized users. BioMed Central 2017-01-31 /pmc/articles/PMC5282659/ /pubmed/28143485 http://dx.doi.org/10.1186/s12917-017-0948-0 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Coertse, Jessica
Markotter, Wanda
le Roux, Kevin
Stewart, Daniel
Sabeta, Claude T.
Nel, Louis H.
New isolations of the rabies-related Mokola virus from South Africa
title New isolations of the rabies-related Mokola virus from South Africa
title_full New isolations of the rabies-related Mokola virus from South Africa
title_fullStr New isolations of the rabies-related Mokola virus from South Africa
title_full_unstemmed New isolations of the rabies-related Mokola virus from South Africa
title_short New isolations of the rabies-related Mokola virus from South Africa
title_sort new isolations of the rabies-related mokola virus from south africa
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282659/
https://www.ncbi.nlm.nih.gov/pubmed/28143485
http://dx.doi.org/10.1186/s12917-017-0948-0
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