Progranulin causes adipose insulin resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress

BACKGROUND: Progranulin (PGRN) has recently emerged as an important regulator for insulin resistance. However, the direct effect of progranulin in adipose insulin resistance associated with the autophagy mechanism is not fully understood. METHODS: In the present study, progranulin was administered t...

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Detalles Bibliográficos
Autores principales: Guo, Qinyue, Xu, Lin, Li, Huixia, Sun, Hongzhi, Liu, Jiali, Wu, Shufang, Zhou, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282713/
https://www.ncbi.nlm.nih.gov/pubmed/28143512
http://dx.doi.org/10.1186/s12944-017-0425-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282713/
https://www.ncbi.nlm.nih.gov/pubmed/28143512
http://dx.doi.org/10.1186/s12944-017-0425-6

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