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Targeting acute myeloid leukemia stem cell signaling by natural products

Acute myeloid leukemia (AML) is the most commonly diagnosed leukemia in adults (25%) and comprises 15–20% in children. It is a genetically heterogeneous aggressive disease characterized by the accumulation of somatically acquired genetic changes, altering self-renewal, proliferation, and differentia...

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Autores principales: Siveen, Kodappully Sivaraman, Uddin, Shahab, Mohammad, Ramzi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282735/
https://www.ncbi.nlm.nih.gov/pubmed/28137265
http://dx.doi.org/10.1186/s12943-016-0571-x
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author Siveen, Kodappully Sivaraman
Uddin, Shahab
Mohammad, Ramzi M.
author_facet Siveen, Kodappully Sivaraman
Uddin, Shahab
Mohammad, Ramzi M.
author_sort Siveen, Kodappully Sivaraman
collection PubMed
description Acute myeloid leukemia (AML) is the most commonly diagnosed leukemia in adults (25%) and comprises 15–20% in children. It is a genetically heterogeneous aggressive disease characterized by the accumulation of somatically acquired genetic changes, altering self-renewal, proliferation, and differentiation of hematopoietic progenitor cells, resulting in uncontrolled clonal proliferation of malignant progenitor myeloid cells in the bone marrow, peripheral blood, and occasionally in other body tissues. Treatment with modern chemotherapy regimen (cytarabine and daunorubicin) usually achieves high remission rates, still majority of patients are found to relapse, resulting in only 40–45% overall 5 year survival in young patients and less than 10% in the elderly AML patients. The leukemia stem cells (LSCs) are characterized by their unlimited self-renewal, repopulating potential and long residence in a quiescent state of G(0)/G(1) phase. LSCs are considered to have a pivotal role in the relapse and refractory of AML. Therefore, new therapeutic strategies to target LSCs with limited toxicity towards the normal hematopoietic population is critical for the ultimate curing of AML. Ongoing research works with natural products like parthenolide (a natural plant extract derived compound) and its derivatives, that have the ability to target multiple pathways that regulate the self-renewal, growth and survival of LSCs point to ways for a possible complete remission in AML. In this review article, we will update and discuss various natural products that can target LSCs in AML.
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spelling pubmed-52827352017-02-03 Targeting acute myeloid leukemia stem cell signaling by natural products Siveen, Kodappully Sivaraman Uddin, Shahab Mohammad, Ramzi M. Mol Cancer Review Acute myeloid leukemia (AML) is the most commonly diagnosed leukemia in adults (25%) and comprises 15–20% in children. It is a genetically heterogeneous aggressive disease characterized by the accumulation of somatically acquired genetic changes, altering self-renewal, proliferation, and differentiation of hematopoietic progenitor cells, resulting in uncontrolled clonal proliferation of malignant progenitor myeloid cells in the bone marrow, peripheral blood, and occasionally in other body tissues. Treatment with modern chemotherapy regimen (cytarabine and daunorubicin) usually achieves high remission rates, still majority of patients are found to relapse, resulting in only 40–45% overall 5 year survival in young patients and less than 10% in the elderly AML patients. The leukemia stem cells (LSCs) are characterized by their unlimited self-renewal, repopulating potential and long residence in a quiescent state of G(0)/G(1) phase. LSCs are considered to have a pivotal role in the relapse and refractory of AML. Therefore, new therapeutic strategies to target LSCs with limited toxicity towards the normal hematopoietic population is critical for the ultimate curing of AML. Ongoing research works with natural products like parthenolide (a natural plant extract derived compound) and its derivatives, that have the ability to target multiple pathways that regulate the self-renewal, growth and survival of LSCs point to ways for a possible complete remission in AML. In this review article, we will update and discuss various natural products that can target LSCs in AML. BioMed Central 2017-01-30 /pmc/articles/PMC5282735/ /pubmed/28137265 http://dx.doi.org/10.1186/s12943-016-0571-x Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Siveen, Kodappully Sivaraman
Uddin, Shahab
Mohammad, Ramzi M.
Targeting acute myeloid leukemia stem cell signaling by natural products
title Targeting acute myeloid leukemia stem cell signaling by natural products
title_full Targeting acute myeloid leukemia stem cell signaling by natural products
title_fullStr Targeting acute myeloid leukemia stem cell signaling by natural products
title_full_unstemmed Targeting acute myeloid leukemia stem cell signaling by natural products
title_short Targeting acute myeloid leukemia stem cell signaling by natural products
title_sort targeting acute myeloid leukemia stem cell signaling by natural products
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282735/
https://www.ncbi.nlm.nih.gov/pubmed/28137265
http://dx.doi.org/10.1186/s12943-016-0571-x
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