Multidisciplinary insight into clonal expansion of HTLV-1–infected cells in adult T-cell leukemia via modeling by deterministic finite automata coupled with high-throughput sequencing

BACKGROUND: Clonal expansion of leukemic cells leads to onset of adult T-cell leukemia (ATL), an aggressive lymphoid malignancy with a very poor prognosis. Infection with human T-cell leukemia virus type-1 (HTLV-1) is the direct cause of ATL onset, and integration of HTLV-1 into the human genome is...

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Detalles Bibliográficos
Autores principales: Farmanbar, Amir, Firouzi, Sanaz, Park, Sung-Joon, Nakai, Kenta, Uchimaru, Kaoru, Watanabe, Toshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282739/
https://www.ncbi.nlm.nih.gov/pubmed/28137248
http://dx.doi.org/10.1186/s12920-016-0241-2

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