Cargando…

A phase II trial of stereotactic body radiotherapy with concurrent anti-PD1 treatment in metastatic melanoma: evaluation of clinical and immunologic response

BACKGROUND: Antibodies blocking programmed cell death 1 (PD-1) have encouraging responses in patients with metastatic melanoma. Response to anti-PD-1 treatment requires pre-existing CD8+ T cells that are negatively regulated by PD-1-mediated adaptive immune resistance. Unfortunately, less than half...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Wolf, Katrien, Kruse, Vibeke, Sundahl, Nora, van Gele, Mireille, Chevolet, Ines, Speeckaert, Reinhart, Brochez, Lieve, Ost, Piet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282822/ https://www.ncbi.nlm.nih.gov/pubmed/28137295 http://dx.doi.org/10.1186/s12967-017-1123-x

Ejemplares similares

Challenging PD-L1 expressing cytotoxic T cells as a predictor for response to immunotherapy in melanoma
por: Brochez, Lieve, et al.
Publicado: (2018)

A phase I/II trial of fixed-dose stereotactic body radiotherapy with sequential or concurrent pembrolizumab in metastatic urothelial carcinoma: evaluation of safety and clinical and immunologic response
por: Sundahl, Nora, et al.
Publicado: (2017)

Immune mediated mechanisms of melanocyte destruction: Paving the way for efficient immunotherapeutic strategies against melanoma
por: Speeckaert, Reinhart, et al.
Publicado: (2012)

Clinical significance of plasmacytoid dendritic cells and myeloid-derived suppressor cells in melanoma
por: Chevolet, Ines, et al.
Publicado: (2015)

Peritumoral endothelial indoleamine 2, 3-dioxygenase expression is an early independent marker of disease relapse in colorectal cancer and is influenced by DNA mismatch repair profile
por: Meireson, Annabel, et al.
Publicado: (2018)

Immune Monitoring in Melanoma and Urothelial Cancer Patients Treated with Anti-PD-1 Immunotherapy and SBRT Discloses Tumor Specific Immune Signatures
por: Meireson, Annabel, et al.
Publicado: (2021)

Clinical Relevance of Serum Kyn/Trp Ratio and Basal and IFNγ-Upregulated IDO1 Expression in Peripheral Monocytes in Early Stage Melanoma
por: Meireson, Annabel, et al.
Publicado: (2021)

Checkpoint inhibition in combination with an immunoboost of external beam radiotherapy in solid tumors (CHEERS): study protocol for a phase 2, open-label, randomized controlled trial
por: Spaas, Mathieu, et al.
Publicado: (2021)

Psoriasis Vulgaris Exacerbation during Treatment with a PD-1 Checkpoint Inhibitor: Case Report and Literature Review
por: De Bock, Marlies, et al.
Publicado: (2018)

Hypomelanoses in Children
por: van Geel, Nanja, et al.
Publicado: (2013)

Editorial: Targeting Indoleamine 2,3-dioxygenases and Tryptophan Dioxygenase for Cancer Immunotherapy
por: Brochez, Lieve, et al.
Publicado: (2021)

Effects of radiation on the metastatic process
por: Sundahl, Nora, et al.
Publicado: (2018)

A Longitudinal Analysis of IDO and PDL1 Expression during Immune- or Targeted Therapy in Advanced Melanoma()
por: Krähenbühl, Lukas, et al.
Publicado: (2018)

Stereotactic Body Radiotherapy for Primary Prostate Cancer
por: Kothari, Gargi, et al.
Publicado: (2018)

Editorial: Immunology of Vitiligo
por: Seneschal, Julien, et al.
Publicado: (2021)

Predicting survival in melanoma patients treated with concurrent targeted- or immunotherapy and stereotactic radiotherapy: Melanoma brain metastases prognostic score
por: Schaule, Jana, et al.
Publicado: (2020)

P-cadherin counteracts myosin II-B function: implications in melanoma progression
por: Jacobs, Koen, et al.
Publicado: (2010)

A phase III randomized-controlled, single-blind trial to improve quality of life with stereotactic body radiotherapy for patients with painful bone metastases (ROBOMET)
por: Mercier, Carole, et al.
Publicado: (2019)

Correction to: Predicting survival in melanoma patients treated with concurrent targeted- or immunotherapy and stereotactic radiotherapy: Melanoma brain metastases prognostic score
por: Schaule, Jana, et al.
Publicado: (2020)

Combined high dose radiation and pazopanib in metastatic renal cell carcinoma: a phase I dose escalation trial
por: De Wolf, Katrien, et al.
Publicado: (2017)

The Confluence of Stereotactic Ablative Radiotherapy and Tumor Immunology
por: Finkelstein, Steven Eric, et al.
Publicado: (2011)

The potential of radiotherapy to enhance the efficacy of renal cell carcinoma therapy
por: De Wolf, Katrien, et al.
Publicado: (2015)

Repeated stereotactic body radiotherapy for oligometastatic prostate cancer recurrence
por: Decaestecker, Karel, et al.
Publicado: (2014)

Synthesis and characterization of non-viral liposomal carriers for the local application of siRNA molecules and anti-miRNAs in the therapeutic treatment of psoriasis
por: Bracke, Stefanie, et al.
Publicado: (2011)

JAK3 as an Emerging Target for Topical Treatment of Inflammatory Skin Diseases
por: Alves de Medeiros, Ana Karina, et al.
Publicado: (2016)

Rehabilitation interventions to improve patient-reported outcomes and physical fitness in survivors of muscle invasive bladder cancer: a systematic review protocol
por: Rammant, Elke, et al.
Publicado: (2017)

Spine Stereotactic Body Radiotherapy Outcomes in Patients with Concurrent Brain Metastases
por: Colaco, Rovel J, et al.
Publicado: (2016)

Radiotherapy for oligometastatic non-small cell lung cancer: a narrative review
por: Sundahl, Nora, et al.
Publicado: (2021)

IDO Expression in Cancer: Different Compartment, Different Functionality?
por: Meireson, Annabel, et al.
Publicado: (2020)

Potential underlying mechanisms of cerebral venous thrombosis associated with COVID-19
por: Speeckaert, Marijn M., et al.
Publicado: (2020)

Vitamin D Sufficiency and COVID-19: Is Vitamin D Binding Protein (and Its Polymorphism) the Missing Link?
por: Speeckaert, Marijn M., et al.
Publicado: (2021)

Genetic polymorphisms, vitamin D binding protein and vitamin D deficiency in COVID-19
por: Speeckaert, Marijn M., et al.
Publicado: (2021)

The biologic importance of the vitamin D binding protein polymorphism in pediatric COVID-19 patients
por: Speeckaert, Marijn M., et al.
Publicado: (2021)

Stereotactic Body Radiotherapy Immunological Planning—A Review With a Proposed Theoretical Model
por: Swamy, Kumara
Publicado: (2022)

Concurrent immunotherapy and re‐irradiation utilizing stereotactic body radiotherapy for recurrent high‐grade gliomas
por: Mahase, Sean S., et al.
Publicado: (2023)

The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach
por: Delrue, Charlotte, et al.
Publicado: (2022)

A meta-analysis of chemokines in vitiligo: Recruiting immune cells towards melanocytes
por: Speeckaert, Reinhart, et al.
Publicado: (2023)

Urinary Extracellular Vesicles in Chronic Kidney Disease: From Bench to Bedside?
por: Delrue, Charlotte, et al.
Publicado: (2023)

Vitamin D Deficiency: An Underestimated Factor in Sepsis?
por: Delrue, Charlotte, et al.
Publicado: (2023)

The Potential Influence of Advanced Glycation End Products and (s)RAGE in Rheumatic Diseases
por: Delrue, Charlotte, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_eftj85082sltb9iu48lvdr7mr3