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APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice

BACKGROUND: APOE genotype is the foremost genetic factor modulating β-amyloid (Aβ) deposition and risk of sporadic Alzheimer’s disease (AD). Here we investigated how APOE genotype influences response to anti-Aβ immunotherapy. METHODS: APP(SW)/PS1(dE9) (APP) transgenic mice with targeted replacement...

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Detalles Bibliográficos
Autores principales:	Pankiewicz, Joanna E, Baquero-Buitrago, Jairo, Sanchez, Sandrine, Lopez-Contreras, Jennifer, Kim, Jungsu, Sullivan, Patrick M., Holtzman, David M., Sadowski, Martin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282859/ https://www.ncbi.nlm.nih.gov/pubmed/28143566 http://dx.doi.org/10.1186/s13024-017-0156-1

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