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Aging and amyloid β oligomers enhance TLR4 expression, LPS-induced Ca(2+) responses, and neuron cell death in cultured rat hippocampal neurons

BACKGROUND: Toll-like receptors (TLRs) are transmembrane pattern-recognition receptors of the innate immune system recognizing diverse pathogen-derived and tissue damage-related ligands. It has been suggested that TLR signaling contributes to the pathogenesis of age-related, neurodegenerative diseas...

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Detalles Bibliográficos
Autores principales:	Calvo-Rodríguez, María, de la Fuente, Carmen, García-Durillo, Mónica, García-Rodríguez, Carmen, Villalobos, Carlos, Núñez, Lucía
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282876/ https://www.ncbi.nlm.nih.gov/pubmed/28143556 http://dx.doi.org/10.1186/s12974-017-0802-0

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