IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights

The insulin-like growth factor-I (IGF-I) signaling induces epithelial to mesenchymal transition (EMT) program and contributes to metastasis and drug resistance in several subtypes of tumors. In preclinical studies, targeting of the insulin-like growth factor-I receptor (IGF-IR) showed promising anti...

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Autores principales: Li, Heming, Batth, Izhar Singh, Qu, Xiujuan, Xu, Ling, Song, Na, Wang, Ruoyu, Liu, Yunpeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282886/
https://www.ncbi.nlm.nih.gov/pubmed/28137302
http://dx.doi.org/10.1186/s12943-016-0576-5
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author Li, Heming
Batth, Izhar Singh
Qu, Xiujuan
Xu, Ling
Song, Na
Wang, Ruoyu
Liu, Yunpeng
author_facet Li, Heming
Batth, Izhar Singh
Qu, Xiujuan
Xu, Ling
Song, Na
Wang, Ruoyu
Liu, Yunpeng
author_sort Li, Heming
collection PubMed
description The insulin-like growth factor-I (IGF-I) signaling induces epithelial to mesenchymal transition (EMT) program and contributes to metastasis and drug resistance in several subtypes of tumors. In preclinical studies, targeting of the insulin-like growth factor-I receptor (IGF-IR) showed promising anti-tumor effects. Unfortunately, high expectations for anti-IGF-IR therapy encountered challenge and disappointment in numerous clinical trials. This review summarizes the regulation of EMT by IGF-I/IGF-IR signaling pathway and drug resistance mechanisms of targeting IGF-IR therapy. Most importantly, we address several factors in the regulation of IGF-I/IGF-IR-associated EMT progression that may be potential predictive biomarkers in targeted therapy.
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spelling pubmed-52828862017-02-03 IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights Li, Heming Batth, Izhar Singh Qu, Xiujuan Xu, Ling Song, Na Wang, Ruoyu Liu, Yunpeng Mol Cancer Review The insulin-like growth factor-I (IGF-I) signaling induces epithelial to mesenchymal transition (EMT) program and contributes to metastasis and drug resistance in several subtypes of tumors. In preclinical studies, targeting of the insulin-like growth factor-I receptor (IGF-IR) showed promising anti-tumor effects. Unfortunately, high expectations for anti-IGF-IR therapy encountered challenge and disappointment in numerous clinical trials. This review summarizes the regulation of EMT by IGF-I/IGF-IR signaling pathway and drug resistance mechanisms of targeting IGF-IR therapy. Most importantly, we address several factors in the regulation of IGF-I/IGF-IR-associated EMT progression that may be potential predictive biomarkers in targeted therapy. BioMed Central 2017-01-30 /pmc/articles/PMC5282886/ /pubmed/28137302 http://dx.doi.org/10.1186/s12943-016-0576-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Li, Heming
Batth, Izhar Singh
Qu, Xiujuan
Xu, Ling
Song, Na
Wang, Ruoyu
Liu, Yunpeng
IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights
title IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights
title_full IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights
title_fullStr IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights
title_full_unstemmed IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights
title_short IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights
title_sort igf-ir signaling in epithelial to mesenchymal transition and targeting igf-ir therapy: overview and new insights
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282886/
https://www.ncbi.nlm.nih.gov/pubmed/28137302
http://dx.doi.org/10.1186/s12943-016-0576-5
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