The evolving concept of liver cancer stem cells

Liver cancer is an often fatal malignant tumor with a high recurrence rate and chemoresistance. The major malignant phenotypes of cancer, including recurrence, metastasis, and chemoresistance, are related to the presence of cancer stem cells (CSCs). In the past few decades, CSCs have been identified...

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Detalles Bibliográficos
Autores principales: Nio, Kouki, Yamashita, Taro, Kaneko, Shuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282887/
https://www.ncbi.nlm.nih.gov/pubmed/28137313
http://dx.doi.org/10.1186/s12943-016-0572-9
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author Nio, Kouki
Yamashita, Taro
Kaneko, Shuichi
author_facet Nio, Kouki
Yamashita, Taro
Kaneko, Shuichi
author_sort Nio, Kouki
collection PubMed
description Liver cancer is an often fatal malignant tumor with a high recurrence rate and chemoresistance. The major malignant phenotypes of cancer, including recurrence, metastasis, and chemoresistance, are related to the presence of cancer stem cells (CSCs). In the past few decades, CSCs have been identified and characterized in many tumors including liver cancer. Accumulated evidence has revealed many aspects of the biological behavior of liver CSCs and the mechanism of their regulation. Based on these findings, a number of studies have investigated eradication of liver CSCs. This review focuses on the recent advances in our understanding of the biology of liver CSCs and the development of strategies for their treatment.
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spelling pubmed-52828872017-02-03 The evolving concept of liver cancer stem cells Nio, Kouki Yamashita, Taro Kaneko, Shuichi Mol Cancer Review Liver cancer is an often fatal malignant tumor with a high recurrence rate and chemoresistance. The major malignant phenotypes of cancer, including recurrence, metastasis, and chemoresistance, are related to the presence of cancer stem cells (CSCs). In the past few decades, CSCs have been identified and characterized in many tumors including liver cancer. Accumulated evidence has revealed many aspects of the biological behavior of liver CSCs and the mechanism of their regulation. Based on these findings, a number of studies have investigated eradication of liver CSCs. This review focuses on the recent advances in our understanding of the biology of liver CSCs and the development of strategies for their treatment. BioMed Central 2017-01-30 /pmc/articles/PMC5282887/ /pubmed/28137313 http://dx.doi.org/10.1186/s12943-016-0572-9 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Nio, Kouki
Yamashita, Taro
Kaneko, Shuichi
The evolving concept of liver cancer stem cells
title The evolving concept of liver cancer stem cells
title_full The evolving concept of liver cancer stem cells
title_fullStr The evolving concept of liver cancer stem cells
title_full_unstemmed The evolving concept of liver cancer stem cells
title_short The evolving concept of liver cancer stem cells
title_sort evolving concept of liver cancer stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282887/
https://www.ncbi.nlm.nih.gov/pubmed/28137313
http://dx.doi.org/10.1186/s12943-016-0572-9
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