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The Thyroid Na+/I- Symporter: Molecular Characterization and Genomic Regulation

Iodide (I-) is an essential constituent of the thyroid hormones triiodothyronine (T(3)) and thyroxine (T(4)), and the iodide concentrating mechanism of the thyroid gland is essential for the synthesis of these hormones. In addition, differential uptake of iodine isotopes (radioiodine) is a key modal...

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Autores principales: Alotaibi, Hani, Tuzlakoğlu-Öztürk, Merve, Tazebay, Uygar Halis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283716/
https://www.ncbi.nlm.nih.gov/pubmed/28117294
http://dx.doi.org/10.4274/2017.26.suppl.11
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author Alotaibi, Hani
Tuzlakoğlu-Öztürk, Merve
Tazebay, Uygar Halis
author_facet Alotaibi, Hani
Tuzlakoğlu-Öztürk, Merve
Tazebay, Uygar Halis
author_sort Alotaibi, Hani
collection PubMed
description Iodide (I-) is an essential constituent of the thyroid hormones triiodothyronine (T(3)) and thyroxine (T(4)), and the iodide concentrating mechanism of the thyroid gland is essential for the synthesis of these hormones. In addition, differential uptake of iodine isotopes (radioiodine) is a key modality for the diagnosis and therapy of thyroid cancer. The sodium dependent iodide transport activity of the thyroid gland is mainly attributed to the functional expression of the Na+/I- Symporter (NIS) localized at the basolateral membrane of thyrocytes. In this paper, we review and summarize current data on molecular characterization, on structure and function of NIS protein, as well as on the transcriptional regulation of NIS encoding gene in the thyroid gland. We also propose that a better and more precise understanding of NIS gene regulation at the molecular level in both healthy and malignant thyroid cells may lead to the identification of small molecule candidates. These could then be translated into clinical practice for better induction and more effective modulation of radioiodine uptake in dedifferentiated thyroid cancer cells and in their distant metastatic lesions.
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spelling pubmed-52837162017-03-27 The Thyroid Na+/I- Symporter: Molecular Characterization and Genomic Regulation Alotaibi, Hani Tuzlakoğlu-Öztürk, Merve Tazebay, Uygar Halis Mol Imaging Radionucl Ther Review Iodide (I-) is an essential constituent of the thyroid hormones triiodothyronine (T(3)) and thyroxine (T(4)), and the iodide concentrating mechanism of the thyroid gland is essential for the synthesis of these hormones. In addition, differential uptake of iodine isotopes (radioiodine) is a key modality for the diagnosis and therapy of thyroid cancer. The sodium dependent iodide transport activity of the thyroid gland is mainly attributed to the functional expression of the Na+/I- Symporter (NIS) localized at the basolateral membrane of thyrocytes. In this paper, we review and summarize current data on molecular characterization, on structure and function of NIS protein, as well as on the transcriptional regulation of NIS encoding gene in the thyroid gland. We also propose that a better and more precise understanding of NIS gene regulation at the molecular level in both healthy and malignant thyroid cells may lead to the identification of small molecule candidates. These could then be translated into clinical practice for better induction and more effective modulation of radioiodine uptake in dedifferentiated thyroid cancer cells and in their distant metastatic lesions. Galenos Publishing 2017-02 2017-01-09 /pmc/articles/PMC5283716/ /pubmed/28117294 http://dx.doi.org/10.4274/2017.26.suppl.11 Text en © Molecular Imaging and Radionuclide Therapy, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Alotaibi, Hani
Tuzlakoğlu-Öztürk, Merve
Tazebay, Uygar Halis
The Thyroid Na+/I- Symporter: Molecular Characterization and Genomic Regulation
title The Thyroid Na+/I- Symporter: Molecular Characterization and Genomic Regulation
title_full The Thyroid Na+/I- Symporter: Molecular Characterization and Genomic Regulation
title_fullStr The Thyroid Na+/I- Symporter: Molecular Characterization and Genomic Regulation
title_full_unstemmed The Thyroid Na+/I- Symporter: Molecular Characterization and Genomic Regulation
title_short The Thyroid Na+/I- Symporter: Molecular Characterization and Genomic Regulation
title_sort thyroid na+/i- symporter: molecular characterization and genomic regulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283716/
https://www.ncbi.nlm.nih.gov/pubmed/28117294
http://dx.doi.org/10.4274/2017.26.suppl.11
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