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Induction of Immune Tolerance to Foreign Protein via Adeno-Associated Viral Vector Gene Transfer in Mid-Gestation Fetal Sheep

A major limitation to adeno-associated virus (AAV) gene therapy is the generation of host immune responses to viral vector antigens and the transgene product. The ability to induce immune tolerance to foreign protein has the potential to overcome this host immunity. Acquisition and maintenance of to...

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Detalles Bibliográficos
Autores principales:	Davey, Marcus G., Riley, John S., Andrews, Abigail, Tyminski, Alec, Limberis, Maria, Pogoriler, Jennifer E., Partridge, Emily, Olive, Aliza, Hedrick, Holly L., Flake, Alan W., Peranteau, William H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283730/ https://www.ncbi.nlm.nih.gov/pubmed/28141818 http://dx.doi.org/10.1371/journal.pone.0171132

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