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Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype

Visceral Leishmaniasis (VL), caused by the intracellular protozoan Leishmania donovani, is characterized by relentlessly increasing visceral parasite replication, cachexia, massive splenomegaly, pancytopenia and ultimately death. Progressive disease is considered to be due to impaired effector T cel...

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Detalles Bibliográficos
Autores principales:	Kong, Fanping, Saldarriaga, Omar A., Spratt, Heidi, Osorio, E. Yaneth, Travi, Bruno L., Luxon, Bruce A., Melby, Peter C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283737/ https://www.ncbi.nlm.nih.gov/pubmed/28141856 http://dx.doi.org/10.1371/journal.ppat.1006165

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