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Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion
To identify cell cycle regulators that enable cancer cells to replicate DNA and divide in an unrestricted manner, we performed a parallel genome-wide RNAi screen in normal and cancer cell lines. In addition to many shared regulators, we found that tumor and normal cells are differentially sensitive...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283814/ https://www.ncbi.nlm.nih.gov/pubmed/27929715 http://dx.doi.org/10.1080/15384101.2016.1261765 |