SUMOylation of Na(V)1.2 channels mediates the early response to acute hypoxia in central neurons

The mechanism for the earliest response of central neurons to hypoxia—an increase in voltage-gated sodium current (I(Na))—has been unknown. Here, we show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cerebellar granule neurons (CGN) and that SUMOylation of Na(V)1.2 c...

Descripción completa

Detalles Bibliográficos
Autores principales: Plant, Leigh D, Marks, Jeremy D, Goldstein, Steve AN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283832/
https://www.ncbi.nlm.nih.gov/pubmed/28029095
http://dx.doi.org/10.7554/eLife.20054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283832/
https://www.ncbi.nlm.nih.gov/pubmed/28029095
http://dx.doi.org/10.7554/eLife.20054

Ejemplares similares