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SUMOylation of Na(V)1.2 channels mediates the early response to acute hypoxia in central neurons
The mechanism for the earliest response of central neurons to hypoxia—an increase in voltage-gated sodium current (I(Na))—has been unknown. Here, we show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cerebellar granule neurons (CGN) and that SUMOylation of Na(V)1.2 c...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283832/ https://www.ncbi.nlm.nih.gov/pubmed/28029095 http://dx.doi.org/10.7554/eLife.20054 |