Matrix-regulated integrin α(v)β(5) maintains α(5)β(1)-dependent desmoplastic traits prognostic of neoplastic recurrence

Desmoplasia, a fibrotic mass including cancer-associated fibroblasts (CAFs) and self-sustaining extracellular matrix (D-ECM), is a puzzling feature of pancreatic ductal adenocarcinoma (PDACs). Conflicting studies have identified tumor-restricting and tumor-promoting roles of PDAC-associated desmopla...

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Detalles Bibliográficos
Autores principales: Franco-Barraza, Janusz, Francescone, Ralph, Luong, Tiffany, Shah, Neelima, Madhani, Raj, Cukierman, Gil, Dulaimi, Essel, Devarajan, Karthik, Egleston, Brian L, Nicolas, Emmanuelle, Katherine Alpaugh, R, Malik, Ruchi, Uzzo, Robert G, Hoffman, John P, Golemis, Erica A, Cukierman, Edna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283834/
https://www.ncbi.nlm.nih.gov/pubmed/28139197
http://dx.doi.org/10.7554/eLife.20600

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