Coronary Spastic Angina Induced after Oral Desmopressin (DDAVP) Administration

A 60-year-old man was prescribed oral desmopressin (1-deamino-8-D-arginine vasopressin acetate trihydrate; DDAVP) for nocturnal polyuria. One week after starting to take desmopressin, he frequently felt chest pain while resting. Coronary angiography revealed no organic stenosis; however, an acetylch...

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Detalles Bibliográficos
Autores principales: Adachi, Yusuke, Sakakura, Kenichi, Akashi, Naoyuki, Wada, Hiroshi, Momomura, Shin-ichi, Fujita, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283960/
https://www.ncbi.nlm.nih.gov/pubmed/27980260
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author Adachi, Yusuke
Sakakura, Kenichi
Akashi, Naoyuki
Wada, Hiroshi
Momomura, Shin-ichi
Fujita, Hideo
author_facet Adachi, Yusuke
Sakakura, Kenichi
Akashi, Naoyuki
Wada, Hiroshi
Momomura, Shin-ichi
Fujita, Hideo
author_sort Adachi, Yusuke
collection PubMed
description A 60-year-old man was prescribed oral desmopressin (1-deamino-8-D-arginine vasopressin acetate trihydrate; DDAVP) for nocturnal polyuria. One week after starting to take desmopressin, he frequently felt chest pain while resting. Coronary angiography revealed no organic stenosis; however, an acetylcholine provocation test showed severe coronary spasm with ST elevation. He was diagnosed with coronary spastic angina, and we stopped the oral desmopressin and added diltiazem. While DDAVP should dilate the coronary vessels in healthy subjects, it may provoke coronary vasospasm in patients with endothelial dysfunction. We should be careful to avoid triggering coronary spasm when administering DDAVP to patients that may have potential endothelial dysfunction.
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spelling pubmed-52839602017-02-01 Coronary Spastic Angina Induced after Oral Desmopressin (DDAVP) Administration Adachi, Yusuke Sakakura, Kenichi Akashi, Naoyuki Wada, Hiroshi Momomura, Shin-ichi Fujita, Hideo Intern Med Case Report A 60-year-old man was prescribed oral desmopressin (1-deamino-8-D-arginine vasopressin acetate trihydrate; DDAVP) for nocturnal polyuria. One week after starting to take desmopressin, he frequently felt chest pain while resting. Coronary angiography revealed no organic stenosis; however, an acetylcholine provocation test showed severe coronary spasm with ST elevation. He was diagnosed with coronary spastic angina, and we stopped the oral desmopressin and added diltiazem. While DDAVP should dilate the coronary vessels in healthy subjects, it may provoke coronary vasospasm in patients with endothelial dysfunction. We should be careful to avoid triggering coronary spasm when administering DDAVP to patients that may have potential endothelial dysfunction. The Japanese Society of Internal Medicine 2016-12-15 /pmc/articles/PMC5283960/ /pubmed/27980260 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Adachi, Yusuke
Sakakura, Kenichi
Akashi, Naoyuki
Wada, Hiroshi
Momomura, Shin-ichi
Fujita, Hideo
Coronary Spastic Angina Induced after Oral Desmopressin (DDAVP) Administration
title Coronary Spastic Angina Induced after Oral Desmopressin (DDAVP) Administration
title_full Coronary Spastic Angina Induced after Oral Desmopressin (DDAVP) Administration
title_fullStr Coronary Spastic Angina Induced after Oral Desmopressin (DDAVP) Administration
title_full_unstemmed Coronary Spastic Angina Induced after Oral Desmopressin (DDAVP) Administration
title_short Coronary Spastic Angina Induced after Oral Desmopressin (DDAVP) Administration
title_sort coronary spastic angina induced after oral desmopressin (ddavp) administration
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283960/
https://www.ncbi.nlm.nih.gov/pubmed/27980260
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