Suppression of the Hypothalamic-pituitary-adrenal Axis by Maximum Androgen Blockade in a Patient with Prostate Cancer

A 78-year-old Japanese man showed suppression of the hypothalamic-pituitary-adrenal axis during maximum androgen blockade (MAB) therapy including chlormadinone acetate (CMA) for prostate cancer. After stopping the MAB therapy, both the basal ACTH level and the response to CRH recovered. While no rep...

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Autores principales: Kondo, Takeshi, Endo, Itsuro, Ooguro, Yukari, Morimoto, Kana, Kurahashi, Kiyoe, Yoshida, Sumiko, Kuroda, Akio, Aihara, Ken-ichi, Matsuhisa, Munehide, Abe, Masahiro, Fukumoto, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283963/
https://www.ncbi.nlm.nih.gov/pubmed/27980263
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author Kondo, Takeshi
Endo, Itsuro
Ooguro, Yukari
Morimoto, Kana
Kurahashi, Kiyoe
Yoshida, Sumiko
Kuroda, Akio
Aihara, Ken-ichi
Matsuhisa, Munehide
Abe, Masahiro
Fukumoto, Seiji
author_facet Kondo, Takeshi
Endo, Itsuro
Ooguro, Yukari
Morimoto, Kana
Kurahashi, Kiyoe
Yoshida, Sumiko
Kuroda, Akio
Aihara, Ken-ichi
Matsuhisa, Munehide
Abe, Masahiro
Fukumoto, Seiji
author_sort Kondo, Takeshi
collection PubMed
description A 78-year-old Japanese man showed suppression of the hypothalamic-pituitary-adrenal axis during maximum androgen blockade (MAB) therapy including chlormadinone acetate (CMA) for prostate cancer. After stopping the MAB therapy, both the basal ACTH level and the response to CRH recovered. While no reports have indicated that CMA suppresses the hypothalamic-pituitary-adrenal axis in patients with prostate cancer, CMA has been shown to inhibit this axis in animals. These observations suggest that we must monitor the hypothalamic-pituitary-adrenal axis in patients treated with CMA, especially under stressful conditions.
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spelling pubmed-52839632017-02-01 Suppression of the Hypothalamic-pituitary-adrenal Axis by Maximum Androgen Blockade in a Patient with Prostate Cancer Kondo, Takeshi Endo, Itsuro Ooguro, Yukari Morimoto, Kana Kurahashi, Kiyoe Yoshida, Sumiko Kuroda, Akio Aihara, Ken-ichi Matsuhisa, Munehide Abe, Masahiro Fukumoto, Seiji Intern Med Case Report A 78-year-old Japanese man showed suppression of the hypothalamic-pituitary-adrenal axis during maximum androgen blockade (MAB) therapy including chlormadinone acetate (CMA) for prostate cancer. After stopping the MAB therapy, both the basal ACTH level and the response to CRH recovered. While no reports have indicated that CMA suppresses the hypothalamic-pituitary-adrenal axis in patients with prostate cancer, CMA has been shown to inhibit this axis in animals. These observations suggest that we must monitor the hypothalamic-pituitary-adrenal axis in patients treated with CMA, especially under stressful conditions. The Japanese Society of Internal Medicine 2016-12-15 /pmc/articles/PMC5283963/ /pubmed/27980263 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kondo, Takeshi
Endo, Itsuro
Ooguro, Yukari
Morimoto, Kana
Kurahashi, Kiyoe
Yoshida, Sumiko
Kuroda, Akio
Aihara, Ken-ichi
Matsuhisa, Munehide
Abe, Masahiro
Fukumoto, Seiji
Suppression of the Hypothalamic-pituitary-adrenal Axis by Maximum Androgen Blockade in a Patient with Prostate Cancer
title Suppression of the Hypothalamic-pituitary-adrenal Axis by Maximum Androgen Blockade in a Patient with Prostate Cancer
title_full Suppression of the Hypothalamic-pituitary-adrenal Axis by Maximum Androgen Blockade in a Patient with Prostate Cancer
title_fullStr Suppression of the Hypothalamic-pituitary-adrenal Axis by Maximum Androgen Blockade in a Patient with Prostate Cancer
title_full_unstemmed Suppression of the Hypothalamic-pituitary-adrenal Axis by Maximum Androgen Blockade in a Patient with Prostate Cancer
title_short Suppression of the Hypothalamic-pituitary-adrenal Axis by Maximum Androgen Blockade in a Patient with Prostate Cancer
title_sort suppression of the hypothalamic-pituitary-adrenal axis by maximum androgen blockade in a patient with prostate cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283963/
https://www.ncbi.nlm.nih.gov/pubmed/27980263
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