Severe Thrombocytopenia and Acute Cytomegalovirus Colitis during Primary Human Immunodeficiency Virus Infection

We herein report the case of a 25-year-old man who was referred to our hospital due to acute cytomegalovirus (CMV) colitis. The initial blood tests showed that the patient had concurrent primary human immunodeficiency virus (HIV) infection and severe thrombocytopenia. Raltegravir-based antiretrovira...

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Autores principales: Furuhata, Masanori, Yanagisawa, Naoki, Nishiki, Shingo, Sasaki, Shugo, Suganuma, Akihiko, Imamura, Akifumi, Ajisawa, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283971/
https://www.ncbi.nlm.nih.gov/pubmed/27980271
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author Furuhata, Masanori
Yanagisawa, Naoki
Nishiki, Shingo
Sasaki, Shugo
Suganuma, Akihiko
Imamura, Akifumi
Ajisawa, Atsushi
author_facet Furuhata, Masanori
Yanagisawa, Naoki
Nishiki, Shingo
Sasaki, Shugo
Suganuma, Akihiko
Imamura, Akifumi
Ajisawa, Atsushi
author_sort Furuhata, Masanori
collection PubMed
description We herein report the case of a 25-year-old man who was referred to our hospital due to acute cytomegalovirus (CMV) colitis. The initial blood tests showed that the patient had concurrent primary human immunodeficiency virus (HIV) infection and severe thrombocytopenia. Raltegravir-based antiretroviral therapy (ART) was initiated without the use of ganciclovir or corticosteroids and resulted in a rapid clinical improvement. Platelet transfusions were only necessary for a short period, and subsequent colonoscopy revealed a completely healed ulcer. This case implies that ART alone could be effective for treating severe thrombocytopenia during primary HIV and CMV coinfection.
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spelling pubmed-52839712017-02-01 Severe Thrombocytopenia and Acute Cytomegalovirus Colitis during Primary Human Immunodeficiency Virus Infection Furuhata, Masanori Yanagisawa, Naoki Nishiki, Shingo Sasaki, Shugo Suganuma, Akihiko Imamura, Akifumi Ajisawa, Atsushi Intern Med Case Report We herein report the case of a 25-year-old man who was referred to our hospital due to acute cytomegalovirus (CMV) colitis. The initial blood tests showed that the patient had concurrent primary human immunodeficiency virus (HIV) infection and severe thrombocytopenia. Raltegravir-based antiretroviral therapy (ART) was initiated without the use of ganciclovir or corticosteroids and resulted in a rapid clinical improvement. Platelet transfusions were only necessary for a short period, and subsequent colonoscopy revealed a completely healed ulcer. This case implies that ART alone could be effective for treating severe thrombocytopenia during primary HIV and CMV coinfection. The Japanese Society of Internal Medicine 2016-12-15 /pmc/articles/PMC5283971/ /pubmed/27980271 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Furuhata, Masanori
Yanagisawa, Naoki
Nishiki, Shingo
Sasaki, Shugo
Suganuma, Akihiko
Imamura, Akifumi
Ajisawa, Atsushi
Severe Thrombocytopenia and Acute Cytomegalovirus Colitis during Primary Human Immunodeficiency Virus Infection
title Severe Thrombocytopenia and Acute Cytomegalovirus Colitis during Primary Human Immunodeficiency Virus Infection
title_full Severe Thrombocytopenia and Acute Cytomegalovirus Colitis during Primary Human Immunodeficiency Virus Infection
title_fullStr Severe Thrombocytopenia and Acute Cytomegalovirus Colitis during Primary Human Immunodeficiency Virus Infection
title_full_unstemmed Severe Thrombocytopenia and Acute Cytomegalovirus Colitis during Primary Human Immunodeficiency Virus Infection
title_short Severe Thrombocytopenia and Acute Cytomegalovirus Colitis during Primary Human Immunodeficiency Virus Infection
title_sort severe thrombocytopenia and acute cytomegalovirus colitis during primary human immunodeficiency virus infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283971/
https://www.ncbi.nlm.nih.gov/pubmed/27980271
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