Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release

OBJECTIVE: Caffeine reduces toxic Ca(2+) signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IP(3)R)-mediated signalling, but effects of other xanthines have not been evaluated, nor effects of xanthines on experimental acute pancreatitis (AP). We have determin...

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Detalles Bibliográficos
Autores principales: Huang, Wei, Cane, Matthew C, Mukherjee, Rajarshi, Szatmary, Peter, Zhang, Xiaoying, Elliott, Victoria, Ouyang, Yulin, Chvanov, Michael, Latawiec, Diane, Wen, Li, Booth, David M, Haynes, Andrea C, Petersen, Ole H, Tepikin, Alexei V, Criddle, David N, Sutton, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Pancreas
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5284483/
https://www.ncbi.nlm.nih.gov/pubmed/26642860
http://dx.doi.org/10.1136/gutjnl-2015-309363

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