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Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications
Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are involved in dynamic processes such as mitochondrial fusion and fission, mitophagy and mitochondrial biogenesis. Type 2 diabetes is characterised by mitochondrial dysfunction, h...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5284490/ https://www.ncbi.nlm.nih.gov/pubmed/28131082 http://dx.doi.org/10.1016/j.redox.2017.01.013 |
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author | Rovira-Llopis, Susana Bañuls, Celia Diaz-Morales, Noelia Hernandez-Mijares, Antonio Rocha, Milagros Victor, Victor M. |
author_facet | Rovira-Llopis, Susana Bañuls, Celia Diaz-Morales, Noelia Hernandez-Mijares, Antonio Rocha, Milagros Victor, Victor M. |
author_sort | Rovira-Llopis, Susana |
collection | PubMed |
description | Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are involved in dynamic processes such as mitochondrial fusion and fission, mitophagy and mitochondrial biogenesis. Type 2 diabetes is characterised by mitochondrial dysfunction, high production of reactive oxygen species (ROS) and low levels of ATP. Mitochondrial fusion is modulated by different proteins, including mitofusin-1 (MFN1), mitofusin-2 (MFN2) and optic atrophy (OPA-1), while fission is controlled by mitochondrial fission 1 (FIS1), dynamin-related protein 1 (DRP1) and mitochondrial fission factor (MFF). PARKIN and (PTEN)-induced putative kinase 1 (PINK1) participate in the process of mitophagy, for which mitochondrial fission is necessary. In this review, we discuss the molecular pathways of mitochondrial dynamics, their impairment under type 2 diabetes, and pharmaceutical approaches for targeting mitochondrial dynamics, such as mitochondrial division inhibitor-1 (mdivi-1), dynasore, P110 and 15-oxospiramilactone. Furthermore, we discuss the pathophysiological implications of impaired mitochondrial dynamics, especially in type 2 diabetes. |
format | Online Article Text |
id | pubmed-5284490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-52844902017-02-08 Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications Rovira-Llopis, Susana Bañuls, Celia Diaz-Morales, Noelia Hernandez-Mijares, Antonio Rocha, Milagros Victor, Victor M. Redox Biol Review Article Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are involved in dynamic processes such as mitochondrial fusion and fission, mitophagy and mitochondrial biogenesis. Type 2 diabetes is characterised by mitochondrial dysfunction, high production of reactive oxygen species (ROS) and low levels of ATP. Mitochondrial fusion is modulated by different proteins, including mitofusin-1 (MFN1), mitofusin-2 (MFN2) and optic atrophy (OPA-1), while fission is controlled by mitochondrial fission 1 (FIS1), dynamin-related protein 1 (DRP1) and mitochondrial fission factor (MFF). PARKIN and (PTEN)-induced putative kinase 1 (PINK1) participate in the process of mitophagy, for which mitochondrial fission is necessary. In this review, we discuss the molecular pathways of mitochondrial dynamics, their impairment under type 2 diabetes, and pharmaceutical approaches for targeting mitochondrial dynamics, such as mitochondrial division inhibitor-1 (mdivi-1), dynasore, P110 and 15-oxospiramilactone. Furthermore, we discuss the pathophysiological implications of impaired mitochondrial dynamics, especially in type 2 diabetes. Elsevier 2017-01-16 /pmc/articles/PMC5284490/ /pubmed/28131082 http://dx.doi.org/10.1016/j.redox.2017.01.013 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Rovira-Llopis, Susana Bañuls, Celia Diaz-Morales, Noelia Hernandez-Mijares, Antonio Rocha, Milagros Victor, Victor M. Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications |
title | Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications |
title_full | Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications |
title_fullStr | Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications |
title_full_unstemmed | Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications |
title_short | Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications |
title_sort | mitochondrial dynamics in type 2 diabetes: pathophysiological implications |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5284490/ https://www.ncbi.nlm.nih.gov/pubmed/28131082 http://dx.doi.org/10.1016/j.redox.2017.01.013 |
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