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Investigation of precursor lesions of polypoidal choroidal vasculopathy using contralateral eye findings

PURPOSE: The purpose was to investigate precursor lesions of polypoidal choroidal vasculopathy (PCV). METHODS: This cross-sectional study involved 276 unaffected contralateral eyes from unilateral PCV patients (Group 1), unilateral typical exudative age-related macular degeneration (AMD) patients (G...

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Autores principales: Kang, Se Woong, Lee, Hoyoung, Bae, Kunho, Shin, Joo Young, Kim, Sang Jin, Kim, Jong Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285414/
https://www.ncbi.nlm.nih.gov/pubmed/27596850
http://dx.doi.org/10.1007/s00417-016-3452-5
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author Kang, Se Woong
Lee, Hoyoung
Bae, Kunho
Shin, Joo Young
Kim, Sang Jin
Kim, Jong Min
author_facet Kang, Se Woong
Lee, Hoyoung
Bae, Kunho
Shin, Joo Young
Kim, Sang Jin
Kim, Jong Min
author_sort Kang, Se Woong
collection PubMed
description PURPOSE: The purpose was to investigate precursor lesions of polypoidal choroidal vasculopathy (PCV). METHODS: This cross-sectional study involved 276 unaffected contralateral eyes from unilateral PCV patients (Group 1), unilateral typical exudative age-related macular degeneration (AMD) patients (Group 2), and unilateral epiretinal membrane patients (Group 3) as age-matched controls. Grayish-yellow sub-retinal or sub-retinal-pigment-epithelial deposits larger than 63 μm in size with irregular but discrete margins were defined as drusen-like deposits (DLDs). The frequencies of DLDs, drusen, and pigmentary changes in each group were compared. RESULTS: DLDs larger than 125 μm in size were found more frequently in Group 1 (19.5 %) than in Groups 2 (3.4 %) and 3 (3.2 %) (p < 0.001). Soft drusen were discovered more frequently in Group 2 eyes than in Groups 1 and 3 (p < 0.001). Pigmentary changes were found more frequently in Groups 1 and 2 compared to Group 3. Compared with the other groups, Group 1 manifested a higher frequency of choroidal vascular hyperpermeability (p < 0.005) and thicker choroid (p < 0.001). CONCLUSIONS: The precursor lesions of PCV are different from those of exudative AMD. DLDs larger than 125 μm and pigmentary changes may be early preclinical markers of PCV. Long-term longitudinal studies are warranted for validation.
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spelling pubmed-52854142017-02-13 Investigation of precursor lesions of polypoidal choroidal vasculopathy using contralateral eye findings Kang, Se Woong Lee, Hoyoung Bae, Kunho Shin, Joo Young Kim, Sang Jin Kim, Jong Min Graefes Arch Clin Exp Ophthalmol Retinal Disorders PURPOSE: The purpose was to investigate precursor lesions of polypoidal choroidal vasculopathy (PCV). METHODS: This cross-sectional study involved 276 unaffected contralateral eyes from unilateral PCV patients (Group 1), unilateral typical exudative age-related macular degeneration (AMD) patients (Group 2), and unilateral epiretinal membrane patients (Group 3) as age-matched controls. Grayish-yellow sub-retinal or sub-retinal-pigment-epithelial deposits larger than 63 μm in size with irregular but discrete margins were defined as drusen-like deposits (DLDs). The frequencies of DLDs, drusen, and pigmentary changes in each group were compared. RESULTS: DLDs larger than 125 μm in size were found more frequently in Group 1 (19.5 %) than in Groups 2 (3.4 %) and 3 (3.2 %) (p < 0.001). Soft drusen were discovered more frequently in Group 2 eyes than in Groups 1 and 3 (p < 0.001). Pigmentary changes were found more frequently in Groups 1 and 2 compared to Group 3. Compared with the other groups, Group 1 manifested a higher frequency of choroidal vascular hyperpermeability (p < 0.005) and thicker choroid (p < 0.001). CONCLUSIONS: The precursor lesions of PCV are different from those of exudative AMD. DLDs larger than 125 μm and pigmentary changes may be early preclinical markers of PCV. Long-term longitudinal studies are warranted for validation. Springer Berlin Heidelberg 2016-09-05 2017 /pmc/articles/PMC5285414/ /pubmed/27596850 http://dx.doi.org/10.1007/s00417-016-3452-5 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Retinal Disorders
Kang, Se Woong
Lee, Hoyoung
Bae, Kunho
Shin, Joo Young
Kim, Sang Jin
Kim, Jong Min
Investigation of precursor lesions of polypoidal choroidal vasculopathy using contralateral eye findings
title Investigation of precursor lesions of polypoidal choroidal vasculopathy using contralateral eye findings
title_full Investigation of precursor lesions of polypoidal choroidal vasculopathy using contralateral eye findings
title_fullStr Investigation of precursor lesions of polypoidal choroidal vasculopathy using contralateral eye findings
title_full_unstemmed Investigation of precursor lesions of polypoidal choroidal vasculopathy using contralateral eye findings
title_short Investigation of precursor lesions of polypoidal choroidal vasculopathy using contralateral eye findings
title_sort investigation of precursor lesions of polypoidal choroidal vasculopathy using contralateral eye findings
topic Retinal Disorders
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285414/
https://www.ncbi.nlm.nih.gov/pubmed/27596850
http://dx.doi.org/10.1007/s00417-016-3452-5
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