Cargando…
Monoacylglycerol lipase inhibitors produce pro- or antidepressant responses via hippocampal CA1 GABAergic synapses
The probability of suffering the mood disorder depression is up to 30% in women and 15% in men during their life span. Pharmacological options for depression are limited: conventional antidepressants have low efficacy and a delayed onset of action (several weeks). Here we investigate the antidepress...
Autores principales: | Wang, Y, Gu, N, Duan, T, Kesner, P, Blaskovits, F, Liu, J, Lu, Y, Tong, L, Gao, F, Harris, C, Mackie, K, Li, J, Tan, Q, Hill, M N, Yuan, Z, Zhang, X |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285470/ https://www.ncbi.nlm.nih.gov/pubmed/27001616 http://dx.doi.org/10.1038/mp.2016.22 |
Ejemplares similares
-
Monoacylglycerol Lipase Regulates Fever Response
por: Sanchez-Alavez, Manuel, et al.
Publicado: (2015) -
Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants
por: Ogawa, Shintaro, et al.
Publicado: (2015) -
N-terminal domain replacement changes an archaeal monoacylglycerol lipase into a triacylglycerol lipase
por: Soni, Surabhi, et al.
Publicado: (2019) -
Conformational Plasticity and Ligand Binding of Bacterial Monoacylglycerol Lipase
por: Rengachari, Srinivasan, et al.
Publicado: (2013) -
Conformational gating, dynamics and allostery in human monoacylglycerol lipase
por: Tyukhtenko, Sergiy, et al.
Publicado: (2020)