SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation

SMARCB1 (SNF5/INI1/BAF47), a core subunit of the SWI/SNF (BAF) chromatin remodeling complex(1,2), is inactivated in nearly all pediatric rhabdoid tumors(3–5). These aggressive cancers are among the most genomically stable(6–8), suggesting an epigenetic mechanism by which SMARCB1 loss drives transfor...

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Detalles Bibliográficos
Autores principales: Wang, Xiaofeng, Lee, Ryan S., Alver, Burak H., Haswell, Jeffrey R., Wang, Su, Mieczkowski, Jakub, Drier, Yotam, Gillespie, Shawn M., Archer, Tenley C., Wu, Jennifer N., Tzvetkov, Evgeni P., Troisi, Emma C., Pomeroy, Scott L., Biegel, Jaclyn A., Tolstorukov, Michael Y., Bernstein, Bradley E., Park, Peter J., Roberts, Charles W. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285474/
https://www.ncbi.nlm.nih.gov/pubmed/27941797
http://dx.doi.org/10.1038/ng.3746

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